Abstract
The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3 h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.
| Original language | English |
|---|---|
| Pages (from-to) | 2736-2741 |
| Number of pages | 6 |
| Journal | Food and Chemical Toxicology |
| Volume | 46 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2008 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Food Science
- Toxicology
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The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice. / Hsu, Dur Zong; Wan, Chang Hsin; Hsu, Hua Fen; Lin, Yung Ming; Liu, Ming Yie.
In: Food and Chemical Toxicology, Vol. 46, No. 8, 01.08.2008, p. 2736-2741.Research output: Contribution to journal › Article
TY - JOUR
T1 - The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice
AU - Hsu, Dur Zong
AU - Wan, Chang Hsin
AU - Hsu, Hua Fen
AU - Lin, Yung Ming
AU - Liu, Ming Yie
PY - 2008/8/1
Y1 - 2008/8/1
N2 - The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3 h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.
AB - The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3 h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.
UR - http://www.scopus.com/inward/record.url?scp=47149115087&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47149115087&partnerID=8YFLogxK
U2 - 10.1016/j.fct.2008.04.029
DO - 10.1016/j.fct.2008.04.029
M3 - Article
C2 - 18539378
AN - SCOPUS:47149115087
VL - 46
SP - 2736
EP - 2741
JO - Food and Chemical Toxicology
JF - Food and Chemical Toxicology
SN - 0278-6915
IS - 8
ER -