The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice

Dur Zong Hsu, Chang Hsin Wan, Hua Fen Hsu, Yung Ming Lin, Ming Yie Liu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3 h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.

Original languageEnglish
Pages (from-to)2736-2741
Number of pages6
JournalFood and Chemical Toxicology
Volume46
Issue number8
DOIs
Publication statusPublished - 2008 Aug 1

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Acute Kidney Injury
protective effect
kidneys
Kidney
Xanthine Oxidase
mice
Superoxides
Hydroxyl Radical
xanthine oxidase
Biochemistry
hydroxyl radicals
Oxidative stress
Chemiluminescence
superoxide anion
Free Radicals
Reactive Oxygen Species
Creatinine
Luminescence
Blood
Lipid Peroxidation

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

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abstract = "The aim of this study was to examine the prophylactic protective effects of 3,4-methylenedioxyphenol (sesamol) on ferric-nitrilotriacetate (Fe-NTA)-induced acute renal damage in mice. We induced acute renal injury in mice by treating them with 4 mg/kg of Fe-NTA for 3 h. We used blood biochemistry, creatinine clearance, and histological examinations to assess renal function. With a high-performance chemiluminescence analyzer, we also determined the hydroxyl radical and superoxide anion levels (free radicals) generated. Renal xanthine oxidase activities were also assessed. Sesamol inhibited Fe-NTA-induced acute renal injury, renal lipid peroxidation, the levels of renal hydroxyl radical and superoxide anion generated, and the activity of xanthine oxidase in mice. Therefore, we concluded that sesamol protected mice against Fe-NTA-induced oxidative-stress-associated acute renal injury by at least partially inhibiting the production of reactive oxygen species.",
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The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice. / Hsu, Dur Zong; Wan, Chang Hsin; Hsu, Hua Fen; Lin, Yung Ming; Liu, Ming Yie.

In: Food and Chemical Toxicology, Vol. 46, No. 8, 01.08.2008, p. 2736-2741.

Research output: Contribution to journalArticle

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