The Quest of Candidate Gene in Alcohol Dependence: The Dopamine D2 Receptor (DRD2) Gene

Sheng Yu Lee, Yun Hsuan Chang, Ru-Band Lu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The cause of alcoholism has been hypothesized as a highly heterogeneous genetic load. Family, twin, and adoption studies suggest a strong genetic component in alcohol dependence. The role of the dopamine D2 receptor (. DRD2) gene in the development of alcohol dependence is controversial. The controversy is due in part to the definitions of subtypes in alcohol dependence. Since 1960, many reports have used biopsychosocial approaches to subtype alcoholism; however, no subtypes have been genetically validated. Four subtypes of alcoholism using comorbidity of alcoholism have been reported: pure alcoholism, anxiety/depression alcoholism, antisocial alcoholism, and bipolar disorder with alcoholism. This chapter reviews recent studies of association of the DRD2 gene with alcoholism subtypes in order to enlighten the inconsistent results of the DRD2 gene with unsubtyped alcoholism.

Original languageEnglish
Title of host publicationFoundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids
PublisherElsevier Inc.
Pages543-551
Number of pages9
Volume1
ISBN (Electronic)9780128003763
ISBN (Print)9780128002131
DOIs
Publication statusPublished - 2016 Mar 23

Fingerprint

Dopamine D2 Receptors
Alcoholism
Genes
Genetic Load
Twin Studies
Bipolar Disorder
Comorbidity
Anxiety

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, S. Y., Chang, Y. H., & Lu, R-B. (2016). The Quest of Candidate Gene in Alcohol Dependence: The Dopamine D2 Receptor (DRD2) Gene. In Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids (Vol. 1, pp. 543-551). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800213-1.00050-X
Lee, Sheng Yu ; Chang, Yun Hsuan ; Lu, Ru-Band. / The Quest of Candidate Gene in Alcohol Dependence : The Dopamine D2 Receptor (DRD2) Gene. Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1 Elsevier Inc., 2016. pp. 543-551
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Lee, SY, Chang, YH & Lu, R-B 2016, The Quest of Candidate Gene in Alcohol Dependence: The Dopamine D2 Receptor (DRD2) Gene. in Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. vol. 1, Elsevier Inc., pp. 543-551. https://doi.org/10.1016/B978-0-12-800213-1.00050-X

The Quest of Candidate Gene in Alcohol Dependence : The Dopamine D2 Receptor (DRD2) Gene. / Lee, Sheng Yu; Chang, Yun Hsuan; Lu, Ru-Band.

Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1 Elsevier Inc., 2016. p. 543-551.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Lee SY, Chang YH, Lu R-B. The Quest of Candidate Gene in Alcohol Dependence: The Dopamine D2 Receptor (DRD2) Gene. In Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids. Vol. 1. Elsevier Inc. 2016. p. 543-551 https://doi.org/10.1016/B978-0-12-800213-1.00050-X