The RARγ selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis

Shun Yuan Jiang; Ding Yen Lin; Rong Yaun Shyu; Uwe Reichert; Ming Yang Yeh

doi:10.1016/S0304-3835(98)00382-6

The RARγ selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis

Shun Yuan Jiang, Ding Yen Lin, Rong Yaun Shyu, Uwe Reichert, Ming Yang Yeh

Department of Biotechnology and Bioindustry Sciences

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Retinoids are differentiation-inducing agents that exhibit multiple functions. Their activities are mediated through interaction with nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR). We have investigated the activities of synthetic retinoids on the growth of five gastric cancer cell lines. The effects of agonists selective for RARα, RARβ and RARγ (AM580, CD2019 and CD437, respectively) on cell growth were determined, in comparison to all-trans retinoic acid, by measuring total cellular DNA. AM580 and CD2019 had little or no effect on the growth of all five cell lines. In contrast, the RARγ agonist CD437 inhibited cell growth up to 90-99% in both retinoic acid sensitive and resistant gastric cancer cells at a concentration of 1 μM. The growth suppression caused by CD437 was accompanied by the induction of apoptosis as judged by morphological criteria and DNA ladder formation. However, the extent of CD437-induced growth suppression was not correlated with RARγ mRNA levels, which indicates that CD437 induces apoptosis in gastric cancer cells via an RARγ independent pathway. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	217-225
Number of pages	9
Journal	Cancer Letters
Volume	137
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3835(98)00382-6
Publication status	Published - 1999 Apr 1

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3835(98)00382-6

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title = "The RARγ selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis",

abstract = "Retinoids are differentiation-inducing agents that exhibit multiple functions. Their activities are mediated through interaction with nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR). We have investigated the activities of synthetic retinoids on the growth of five gastric cancer cell lines. The effects of agonists selective for RARα, RARβ and RARγ (AM580, CD2019 and CD437, respectively) on cell growth were determined, in comparison to all-trans retinoic acid, by measuring total cellular DNA. AM580 and CD2019 had little or no effect on the growth of all five cell lines. In contrast, the RARγ agonist CD437 inhibited cell growth up to 90-99% in both retinoic acid sensitive and resistant gastric cancer cells at a concentration of 1 μM. The growth suppression caused by CD437 was accompanied by the induction of apoptosis as judged by morphological criteria and DNA ladder formation. However, the extent of CD437-induced growth suppression was not correlated with RARγ mRNA levels, which indicates that CD437 induces apoptosis in gastric cancer cells via an RARγ independent pathway. Copyright (C) 1999 Elsevier Science Ireland Ltd.",

author = "Jiang, {Shun Yuan} and Lin, {Ding Yen} and Shyu, {Rong Yaun} and Uwe Reichert and Yeh, {Ming Yang}",

note = "Funding Information: This study was supported in part by grants from the National Science Council of the ROC (NSC85-2331-B-016-015), Academia Sinica (CRC85-S02) and Tri-Service General Hospital, Republic of China. The authors would like to thank Dr. P. Chambon for providing the RARγ cDNA, Dr. C.-L. Meng, Dr. T.-M. Chang, Dr. E. Tahara and Dr. V.C. Jordan for providing SC-M1, TMC-1, TMK-1 and MDA-MB-23 1 CL10A cells, respectively.",

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AU - Jiang, Shun Yuan

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AU - Shyu, Rong Yaun

AU - Reichert, Uwe

AU - Yeh, Ming Yang

N1 - Funding Information: This study was supported in part by grants from the National Science Council of the ROC (NSC85-2331-B-016-015), Academia Sinica (CRC85-S02) and Tri-Service General Hospital, Republic of China. The authors would like to thank Dr. P. Chambon for providing the RARγ cDNA, Dr. C.-L. Meng, Dr. T.-M. Chang, Dr. E. Tahara and Dr. V.C. Jordan for providing SC-M1, TMC-1, TMK-1 and MDA-MB-23 1 CL10A cells, respectively.

PY - 1999/4/1

Y1 - 1999/4/1

N2 - Retinoids are differentiation-inducing agents that exhibit multiple functions. Their activities are mediated through interaction with nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR). We have investigated the activities of synthetic retinoids on the growth of five gastric cancer cell lines. The effects of agonists selective for RARα, RARβ and RARγ (AM580, CD2019 and CD437, respectively) on cell growth were determined, in comparison to all-trans retinoic acid, by measuring total cellular DNA. AM580 and CD2019 had little or no effect on the growth of all five cell lines. In contrast, the RARγ agonist CD437 inhibited cell growth up to 90-99% in both retinoic acid sensitive and resistant gastric cancer cells at a concentration of 1 μM. The growth suppression caused by CD437 was accompanied by the induction of apoptosis as judged by morphological criteria and DNA ladder formation. However, the extent of CD437-induced growth suppression was not correlated with RARγ mRNA levels, which indicates that CD437 induces apoptosis in gastric cancer cells via an RARγ independent pathway. Copyright (C) 1999 Elsevier Science Ireland Ltd.

AB - Retinoids are differentiation-inducing agents that exhibit multiple functions. Their activities are mediated through interaction with nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR). We have investigated the activities of synthetic retinoids on the growth of five gastric cancer cell lines. The effects of agonists selective for RARα, RARβ and RARγ (AM580, CD2019 and CD437, respectively) on cell growth were determined, in comparison to all-trans retinoic acid, by measuring total cellular DNA. AM580 and CD2019 had little or no effect on the growth of all five cell lines. In contrast, the RARγ agonist CD437 inhibited cell growth up to 90-99% in both retinoic acid sensitive and resistant gastric cancer cells at a concentration of 1 μM. The growth suppression caused by CD437 was accompanied by the induction of apoptosis as judged by morphological criteria and DNA ladder formation. However, the extent of CD437-induced growth suppression was not correlated with RARγ mRNA levels, which indicates that CD437 induces apoptosis in gastric cancer cells via an RARγ independent pathway. Copyright (C) 1999 Elsevier Science Ireland Ltd.

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The RARγ selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis

Abstract

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