TY - JOUR
T1 - The realiability of intradiscal stress profilometry in cadaveric lumbar dics
AU - Gay, Ralph E.
AU - Zhao, Kristin D.
AU - Ilharreborde, Brice
AU - Bridges, Jonathan
AU - An, Kai Nan
N1 - Funding Information:
We would like to thank A. Gabriela Rosales, MS, from the Division of Biostatistics for her assistance with statistical analysis. This study was funded by the National Center for Complementary and Alternative Medicine, NIH Grant No. K07-AT00972.
PY - 2006/12
Y1 - 2006/12
N2 - The measurement of intradiscal stress has been primarily limited to nucleus pulposus pressure. Intradiscal stress profilometry is a technique that measures stress in both the nucleus pulposus (hydrostatic) and annulus fibrosus (compression). Evidence from animal studies suggests that distraction may affect disc physiology and promote repair. A study was performed to determine the reliability of intradiscal stress profilometry measurements in the anterior, posterior, and nucleus regions of cadaveric lumbar discs. Four fresh-frozen human lumbar motion segments were prepared and tested. Five profiles were obtained during two conditions of compression and three conditions of distraction. Discs were then graded for degenerative change. Reliability was judged by within-specimen coefficients of variation. The coefficients of variation were smaller (more reliable) for compression conditions than for distraction conditions. Within-specimen coefficients during compression ranged from 1.58% to 37.2% in the nucleus, 3.9% to 67.4% in the anterior annulus, and 2.3% to 25.5% in the posterior annulus. The reliability of intradiscal stress profilometry is acceptable for repeated measures studies evaluating within-specimen changes, but the sample size will vary depending on the test conditions used and the disc region of interest.
AB - The measurement of intradiscal stress has been primarily limited to nucleus pulposus pressure. Intradiscal stress profilometry is a technique that measures stress in both the nucleus pulposus (hydrostatic) and annulus fibrosus (compression). Evidence from animal studies suggests that distraction may affect disc physiology and promote repair. A study was performed to determine the reliability of intradiscal stress profilometry measurements in the anterior, posterior, and nucleus regions of cadaveric lumbar discs. Four fresh-frozen human lumbar motion segments were prepared and tested. Five profiles were obtained during two conditions of compression and three conditions of distraction. Discs were then graded for degenerative change. Reliability was judged by within-specimen coefficients of variation. The coefficients of variation were smaller (more reliable) for compression conditions than for distraction conditions. Within-specimen coefficients during compression ranged from 1.58% to 37.2% in the nucleus, 3.9% to 67.4% in the anterior annulus, and 2.3% to 25.5% in the posterior annulus. The reliability of intradiscal stress profilometry is acceptable for repeated measures studies evaluating within-specimen changes, but the sample size will vary depending on the test conditions used and the disc region of interest.
UR - http://www.scopus.com/inward/record.url?scp=34547132061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547132061&partnerID=8YFLogxK
U2 - 10.1142/S0218957706001844
DO - 10.1142/S0218957706001844
M3 - Article
AN - SCOPUS:34547132061
VL - 10
SP - 163
EP - 171
JO - Journal of Musculoskeletal Research
JF - Journal of Musculoskeletal Research
SN - 0218-9577
IS - 4
ER -