TY - JOUR
T1 - The regulation of shrimp metabolism by the white spot syndrome virus (WSSV)
AU - Kumar, Ramya
AU - Huang, Jiun Yan
AU - Ng, Yen Siong
AU - Chen, Cong Yan
AU - Wang, Han Ching
N1 - Funding Information:
This study was supported financially by the Ministry of Science and Technology (MOST 108-2314-B-006-096-MY3; MOST 110-2634-F-006-019). The authors thank Mr. Paul Barlow, National Cheng Kung University and Prof. John Kastelic, The University of Calgary, for their helpful criticism of the manuscript.
Funding Information:
This study was supported financially by the Ministry of Science and Technology (MOST 108‐2314‐B‐006‐096‐MY3; MOST 110‐2634‐F‐006‐019). The authors thank Mr. Paul Barlow, National Cheng Kung University and Prof. John Kastelic, The University of Calgary, for their helpful criticism of the manuscript.
Publisher Copyright:
© 2021 The Authors. Reviews in Aquaculture published by John Wiley & Sons Australia, Ltd.
PY - 2022/6
Y1 - 2022/6
N2 - For more than three decades, infectious diseases have been one of the major causes of economic losses in the global shrimp industry. One of the deadliest of the shrimp pathogens is white spot syndrome virus (WSSV), which causes mass mortality in farmed shrimp. Various aspects of WSSV pathogenicity have been studied, but in this review, we will focus only on one of them, namely metabolic reprogramming. WSSV’s modulation of host metabolism affects glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis and lipid metabolism. Several signaling pathways are involved in this regulation, including JAK-STAT, PI3K-AKT-mTOR, MAPK and Ras-Raf-MEK, with the PI3K-Akt-mTOR pathway in particular playing a critical role in activating the WSSV-induced Warburg effect. Taken together, these changes benefit the virus by facilitating WSSV replication. In this review, we summarize current knowledge regarding the metabolism-related aspects of WSSV pathogenesis, and discuss the mechanisms by which this virus reprograms its host's metabolic pathways. A deeper understanding of these pathways, key metabolic enzymes and signaling mechanisms is potentially important for the development of effective anti-WSSV strategies.
AB - For more than three decades, infectious diseases have been one of the major causes of economic losses in the global shrimp industry. One of the deadliest of the shrimp pathogens is white spot syndrome virus (WSSV), which causes mass mortality in farmed shrimp. Various aspects of WSSV pathogenicity have been studied, but in this review, we will focus only on one of them, namely metabolic reprogramming. WSSV’s modulation of host metabolism affects glycolysis, the tricarboxylic acid (TCA) cycle, glutaminolysis and lipid metabolism. Several signaling pathways are involved in this regulation, including JAK-STAT, PI3K-AKT-mTOR, MAPK and Ras-Raf-MEK, with the PI3K-Akt-mTOR pathway in particular playing a critical role in activating the WSSV-induced Warburg effect. Taken together, these changes benefit the virus by facilitating WSSV replication. In this review, we summarize current knowledge regarding the metabolism-related aspects of WSSV pathogenesis, and discuss the mechanisms by which this virus reprograms its host's metabolic pathways. A deeper understanding of these pathways, key metabolic enzymes and signaling mechanisms is potentially important for the development of effective anti-WSSV strategies.
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U2 - 10.1111/raq.12643
DO - 10.1111/raq.12643
M3 - Review article
AN - SCOPUS:85120580731
SN - 1753-5123
VL - 14
SP - 1150
EP - 1169
JO - Reviews in Aquaculture
JF - Reviews in Aquaculture
IS - 3
ER -