TY - JOUR
T1 - The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease
AU - Tung, Chih Wei
AU - Huang, Pin Yu
AU - Chan, Siew Chin
AU - Cheng, Pei Hsun
AU - Yang, Shang Hsun
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology (108-2314-B-006 -079 -MY3).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Huntington’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and further influences motor and cognitive ability, leading to the suffering of devastating symptoms in HD patients. MicroRNA (miRNA) is a non-coding RNA, and is responsible for gene regulation at post-transcriptional levels in cells. Since one miRNA targets to several downstream genes, it may regulate different pathways simultaneously. As a result, it raises a potential therapy for different diseases using miRNAs, especially for inherited diseases. In this review, we will not only introduce the update information of HD and miRNA, but also discuss the development of potential miRNA-based therapy in HD. With the understanding toward the progression of miRNA studies in HD, we anticipate it may provide an insight to treat this devastating disease, even applying to other genetic diseases.
AB - Huntington’s disease (HD) is one of neurodegenerative diseases, and is defined as a monogenetic disease due to the mutation of Huntingtin gene. This disease affects several cellular functions in neurons, and further influences motor and cognitive ability, leading to the suffering of devastating symptoms in HD patients. MicroRNA (miRNA) is a non-coding RNA, and is responsible for gene regulation at post-transcriptional levels in cells. Since one miRNA targets to several downstream genes, it may regulate different pathways simultaneously. As a result, it raises a potential therapy for different diseases using miRNAs, especially for inherited diseases. In this review, we will not only introduce the update information of HD and miRNA, but also discuss the development of potential miRNA-based therapy in HD. With the understanding toward the progression of miRNA studies in HD, we anticipate it may provide an insight to treat this devastating disease, even applying to other genetic diseases.
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U2 - 10.1186/s12929-021-00755-1
DO - 10.1186/s12929-021-00755-1
M3 - Review article
C2 - 34412645
AN - SCOPUS:85112778812
SN - 1021-7770
VL - 28
JO - Journal of biomedical science
JF - Journal of biomedical science
IS - 1
M1 - 59
ER -