The relationship between high-density lipoprotein cholesterol levels and arterial stiffness in a Taiwanese population

W. C. Shen, F. H. Lu, Y. C. Yang, J. S. Wu, Y. F. Chang, Y. H. Huang, C. J. Chang

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Abstract

Background and aims There are few studies on the association between HDL-C levels and arterial stiffness (AS). HDL-C levels vary in males and females, and it is not clear whether the relationship between HDL-C levels and AS is influenced by gender. The purpose of this study was to investigate gender differences in the association between HDL-C levels and AS in adults. Methods and Results After excluding subjects using lipid-lowering agent, 7254 subjects were enrolled. The AS was assessed by measuring the brachial-ankle pulse wave velocity (baPWV) value. The quartiles of HDL-C were <38, 38–45, 45–53 and >53 mg/dL in men and <48, 48–57, 57–69 and >68 mg/dL in women, respectively. In subjects aged <50 years, none of the HDL-C quartiles were associated with baPWV values. In subjects aged ≥50 years, the highest quartile of HDL-C (beta: −37.57, 95% CI: −61.61 to −13.54) was negatively related to baPWV values. When considering gender difference in subjects aged ≥50 years, the highest quartile of HDL-C (Q4 beta: −57.22, 95% CI: −95.63 to −18.81) was inversely associated with baPWV values in women, but none of the HDL-C quartiles were related to baPWV values in men. Conclusions A high HDL-C level was associated with a lower risk of AS in subjects aged ≥50 years in women but not in men, although this relationship was not apparent in subjects aged <50 years. The association between HDL-C level and AS is thus influenced by gender in people aged ≥50 years.

Original languageEnglish
Pages (from-to)1136-1142
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume27
Issue number12
DOIs
Publication statusPublished - 2017 Dec

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Vascular Stiffness
Pulse Wave Analysis
HDL Cholesterol
Ankle
Arm
Population
Lipids

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

@article{ed37e11231b64a2b9f558a3cf7139fac,
title = "The relationship between high-density lipoprotein cholesterol levels and arterial stiffness in a Taiwanese population",
abstract = "Background and aims There are few studies on the association between HDL-C levels and arterial stiffness (AS). HDL-C levels vary in males and females, and it is not clear whether the relationship between HDL-C levels and AS is influenced by gender. The purpose of this study was to investigate gender differences in the association between HDL-C levels and AS in adults. Methods and Results After excluding subjects using lipid-lowering agent, 7254 subjects were enrolled. The AS was assessed by measuring the brachial-ankle pulse wave velocity (baPWV) value. The quartiles of HDL-C were <38, 38–45, 45–53 and >53 mg/dL in men and <48, 48–57, 57–69 and >68 mg/dL in women, respectively. In subjects aged <50 years, none of the HDL-C quartiles were associated with baPWV values. In subjects aged ≥50 years, the highest quartile of HDL-C (beta: −37.57, 95{\%} CI: −61.61 to −13.54) was negatively related to baPWV values. When considering gender difference in subjects aged ≥50 years, the highest quartile of HDL-C (Q4 beta: −57.22, 95{\%} CI: −95.63 to −18.81) was inversely associated with baPWV values in women, but none of the HDL-C quartiles were related to baPWV values in men. Conclusions A high HDL-C level was associated with a lower risk of AS in subjects aged ≥50 years in women but not in men, although this relationship was not apparent in subjects aged <50 years. The association between HDL-C level and AS is thus influenced by gender in people aged ≥50 years.",
author = "Shen, {W. C.} and Lu, {F. H.} and Yang, {Y. C.} and Wu, {J. S.} and Chang, {Y. F.} and Huang, {Y. H.} and Chang, {C. J.}",
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TY - JOUR

T1 - The relationship between high-density lipoprotein cholesterol levels and arterial stiffness in a Taiwanese population

AU - Shen, W. C.

AU - Lu, F. H.

AU - Yang, Y. C.

AU - Wu, J. S.

AU - Chang, Y. F.

AU - Huang, Y. H.

AU - Chang, C. J.

PY - 2017/12

Y1 - 2017/12

N2 - Background and aims There are few studies on the association between HDL-C levels and arterial stiffness (AS). HDL-C levels vary in males and females, and it is not clear whether the relationship between HDL-C levels and AS is influenced by gender. The purpose of this study was to investigate gender differences in the association between HDL-C levels and AS in adults. Methods and Results After excluding subjects using lipid-lowering agent, 7254 subjects were enrolled. The AS was assessed by measuring the brachial-ankle pulse wave velocity (baPWV) value. The quartiles of HDL-C were <38, 38–45, 45–53 and >53 mg/dL in men and <48, 48–57, 57–69 and >68 mg/dL in women, respectively. In subjects aged <50 years, none of the HDL-C quartiles were associated with baPWV values. In subjects aged ≥50 years, the highest quartile of HDL-C (beta: −37.57, 95% CI: −61.61 to −13.54) was negatively related to baPWV values. When considering gender difference in subjects aged ≥50 years, the highest quartile of HDL-C (Q4 beta: −57.22, 95% CI: −95.63 to −18.81) was inversely associated with baPWV values in women, but none of the HDL-C quartiles were related to baPWV values in men. Conclusions A high HDL-C level was associated with a lower risk of AS in subjects aged ≥50 years in women but not in men, although this relationship was not apparent in subjects aged <50 years. The association between HDL-C level and AS is thus influenced by gender in people aged ≥50 years.

AB - Background and aims There are few studies on the association between HDL-C levels and arterial stiffness (AS). HDL-C levels vary in males and females, and it is not clear whether the relationship between HDL-C levels and AS is influenced by gender. The purpose of this study was to investigate gender differences in the association between HDL-C levels and AS in adults. Methods and Results After excluding subjects using lipid-lowering agent, 7254 subjects were enrolled. The AS was assessed by measuring the brachial-ankle pulse wave velocity (baPWV) value. The quartiles of HDL-C were <38, 38–45, 45–53 and >53 mg/dL in men and <48, 48–57, 57–69 and >68 mg/dL in women, respectively. In subjects aged <50 years, none of the HDL-C quartiles were associated with baPWV values. In subjects aged ≥50 years, the highest quartile of HDL-C (beta: −37.57, 95% CI: −61.61 to −13.54) was negatively related to baPWV values. When considering gender difference in subjects aged ≥50 years, the highest quartile of HDL-C (Q4 beta: −57.22, 95% CI: −95.63 to −18.81) was inversely associated with baPWV values in women, but none of the HDL-C quartiles were related to baPWV values in men. Conclusions A high HDL-C level was associated with a lower risk of AS in subjects aged ≥50 years in women but not in men, although this relationship was not apparent in subjects aged <50 years. The association between HDL-C level and AS is thus influenced by gender in people aged ≥50 years.

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U2 - 10.1016/j.numecd.2017.10.003

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JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

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