The relationship between medication adherence and rehospitalization

A prospective study of schizophrenia patients discharged from psychiatric acute wards

Wen Chuan Shao, Hung Chen, Ya Fen Chang, Wei Chen Lin, Esther Ching-lan Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Antipsychotics have been regarded as the most effective therapy for schizophrenia; however, Taiwan's non-adherence rate for prescribed antipsychotics of 50-80% is an important issue that relates directly and significantly to schizophrenia patient relapse rates. Purposes: This study examines the correlational and predictive relationships between medication adherence and rehospitalization in schizophrenia patients discharged from an acute ward. Methods: This study used a prospective research design. Schizophrenia patients discharged from a psychiatric acute ward who stated their plan to live in the community were recruited as participants. Participant medication adherence was assessed via home visits during the 6-month follow-up period using scales including the Medication Adherence Questionnaire (MAQ), drug attitudes, and regimen knowledge. Rehospitalization data were retrieved from electronic medical records. Relationships between medication adherence and rehospitalization were analyzed using t-tests and regression analysis. Results: Seventy-seven patients with schizophrenia discharged from the acute ward were recruited in accordance with sampling criteria. The majority were male, young, unmarried, had poorer global function, had 12 years of education, and were not rehospitalized during the past 6-month period. Using binomial regression analysis, we found the relative risk for number of rehospitalizations during the 6-month period to be significantly less and the average scores for the total scale, attitude subscale, and knowledge subscale of medication adherence to have increased (0.194-0.79 times). Conclusions / Implications for Practice: Our findings support that better medication adherence in people with schizophrenia decreases rehospitalization risk. We urge clinicians to develop sensitive interventions to promote antipsychotics adherence in this population.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalJournal of Nursing
Volume60
Issue number5
DOIs
Publication statusPublished - 2013 Oct

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Medication Adherence
Psychiatry
Schizophrenia
Prospective Studies
Antipsychotic Agents
Regression Analysis
House Calls
Electronic Health Records
Taiwan
Research Design
Education
Recurrence
Pharmaceutical Preparations
Population

All Science Journal Classification (ASJC) codes

  • Nursing(all)
  • Medicine(all)

Cite this

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abstract = "Background: Antipsychotics have been regarded as the most effective therapy for schizophrenia; however, Taiwan's non-adherence rate for prescribed antipsychotics of 50-80{\%} is an important issue that relates directly and significantly to schizophrenia patient relapse rates. Purposes: This study examines the correlational and predictive relationships between medication adherence and rehospitalization in schizophrenia patients discharged from an acute ward. Methods: This study used a prospective research design. Schizophrenia patients discharged from a psychiatric acute ward who stated their plan to live in the community were recruited as participants. Participant medication adherence was assessed via home visits during the 6-month follow-up period using scales including the Medication Adherence Questionnaire (MAQ), drug attitudes, and regimen knowledge. Rehospitalization data were retrieved from electronic medical records. Relationships between medication adherence and rehospitalization were analyzed using t-tests and regression analysis. Results: Seventy-seven patients with schizophrenia discharged from the acute ward were recruited in accordance with sampling criteria. The majority were male, young, unmarried, had poorer global function, had 12 years of education, and were not rehospitalized during the past 6-month period. Using binomial regression analysis, we found the relative risk for number of rehospitalizations during the 6-month period to be significantly less and the average scores for the total scale, attitude subscale, and knowledge subscale of medication adherence to have increased (0.194-0.79 times). Conclusions / Implications for Practice: Our findings support that better medication adherence in people with schizophrenia decreases rehospitalization risk. We urge clinicians to develop sensitive interventions to promote antipsychotics adherence in this population.",
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The relationship between medication adherence and rehospitalization : A prospective study of schizophrenia patients discharged from psychiatric acute wards. / Shao, Wen Chuan; Chen, Hung; Chang, Ya Fen; Lin, Wei Chen; Lin, Esther Ching-lan.

In: Journal of Nursing, Vol. 60, No. 5, 10.2013, p. 31-40.

Research output: Contribution to journalArticle

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