The relationship between serotonin receptor 1B polymorphisms A-161T and alcohol dependence

Sheng Yu Lee, Wei Wen Lin, San Yuan Huang, Po Hsiu Kuo, Chen Lin Wang, Pei Lin Wu, Shiou Lan Chen, Jo Yung Wei Wu, Huei Chen Ko, Ru Band Lu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background: Several studies have suggested that the serotonin receptor 1B gene (5HT1B) may be important in the pathogenesis of alcohol dependence (alcoholism; ALC; AD). We examined whether 5HT1B gene A-161T polymorphisms (rs130058) are a susceptibility factor for total AD and subgroups of AD. We further explored correlation of this 5HT1B gene variant between anxiety-depression alcoholism (ANX/DEP ALC) and antisocial alcoholism (antisocial ALC) subgroups because of the high comorbidity of anxiety-depression, antisocial personality disorder, and AD. Methods: We recruited 522 Han Chinese in Taiwan for this study: 322 AD patients and 200 controls. The patient group was recruited primarily from medical teaching hospitals; patients with antisocial alcoholism were recruited from Taiwanese prisons. Individuals with AD were classified into 3 homogeneous clinical subgroups - pure alcoholism (pure ALC), ANX/DEP ALC, and antisocial ALC - using DSM-IV diagnosis. The 5HT1B gene A-161T polymorphism was determined using PCR-RFLP. Results: No significant differences in genotypic and allelic frequencies were found between controls and the total AD group or between controls and the 3 AD subgroups. However, there were significant differences in the 5HT1B gene A-161T polymorphism at both the genotype and allelic levels between the ANX/DEP ALC and antisocial ALC subgroups. Conclusions: This study suggests that the 5HT1B gene A-161T polymorphism alone is not a risk factor for increasing susceptibility to either AD or its subtypes. However, 5HT1B gene A-161T polymorphisms might be one of the common genetic factors between the ANX/DEP ALC and antisocial ALC subgroups.

Original languageEnglish
Pages (from-to)1589-1595
Number of pages7
JournalAlcoholism: Clinical and Experimental Research
Volume33
Issue number9
DOIs
Publication statusPublished - 2009 Sept

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

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