The role of bcl-2 in the progression of the colorectal adenoma-carcinoma sequence

Hsiao Bai Yang, Nan-Haw Chow, Bor-Shyang Sheu, Shih-Huang Chan, Chung Ho Chien, Ih Jen Su

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: The bcl-2 proto-oncogene is a known inhibitor of apoptosis that may allow the accumulation and propagation of cells containing genetic alterations. Methods: An immunohistochemical study was performed to examine the role of BCL-2 protein expression in normal colonic mucosa, adenoma, and adenocarcinoma. Results: BCL-2 was present in the crypt base of normal mucosal glands, while diffuse expression of protein product was observed in 69 cases (65.1%) of adenoma and 29 cases (60%) of adenocarcinoma (p > 0.5). A diffuse expression pattern was often noted in adenomas of the tubular type, solitary lesions, small lesions (< 1 cm), and those with mild glandular dysplasia (p < 0.05, respectively). There was, however, no apparent difference as to location, Yamada type of gross appearance, and gender of patients (p > 0.05, respectively). Patterns of BCL-2 expression did not correlate with the biologic indicators of adenocarcinoma (p > 0.1, respectively). Conclusions: Our results support that bcl-2 may play an important role in the early stage of the adenoma-carcinoma sequence. Down-regulation of bcl-2 is associated with the risk of malignant transformation for colorectal adenoma.

Original languageEnglish
Pages (from-to)727-730
Number of pages4
JournalAnticancer research
Volume19
Issue number1 B
Publication statusPublished - 1999 Apr 20

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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