TY - JOUR
T1 - The role of IL-20 in chronic kidney disease and diabetic nephropathy
T2 - Pathogenic and therapeutic implications
AU - Chang, Ming Shi
AU - Hsu, Yu Hsiang
N1 - Funding Information:
This work was supported by the Ministry of Science and Technology of Taiwan (NSC 106-2311-B-006-008-MY2 and NSC 106-2320-B-006-024).
Publisher Copyright:
©2018 Society for Leukocyte Biology
PY - 2018/11
Y1 - 2018/11
N2 - Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.
AB - Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.
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U2 - 10.1002/JLB.MR1217-489R
DO - 10.1002/JLB.MR1217-489R
M3 - Review article
C2 - 29999545
AN - SCOPUS:85050627028
VL - 104
SP - 919
EP - 923
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 5
ER -
