Abstract
Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.
| Original language | English |
|---|---|
| Pages (from-to) | 919-923 |
| Number of pages | 5 |
| Journal | Journal of Leukocyte Biology |
| Volume | 104 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2018 Nov 1 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
- Cell Biology
Cite this
}
The role of IL-20 in chronic kidney disease and diabetic nephropathy : Pathogenic and therapeutic implications. / Chang, Ming-Shi; Hsu, Yu-Hsiang.
In: Journal of Leukocyte Biology, Vol. 104, No. 5, 01.11.2018, p. 919-923.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The role of IL-20 in chronic kidney disease and diabetic nephropathy
T2 - Pathogenic and therapeutic implications
AU - Chang, Ming-Shi
AU - Hsu, Yu-Hsiang
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.
AB - Chronic kidney disease and its complications are a major public health problem worldwide. Diabetic nephropathy has become the main contributing cause of terminal renal failure. There are now evidences that different inflammatory molecules, including proinflammatory cytokines, play a critical role in the development of microvascular diabetic complications, including nephropathy. IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, and renal failure. This review discusses the role of IL-20 as a pathogenic factor in renal injury, focusing on chronic kidney disease and diabetic nephropathy, and describes potential treatment strategies based on modulation of IL-20's function.
UR - http://www.scopus.com/inward/record.url?scp=85050627028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050627028&partnerID=8YFLogxK
U2 - 10.1002/JLB.MR1217-489R
DO - 10.1002/JLB.MR1217-489R
M3 - Review article
C2 - 29999545
AN - SCOPUS:85050627028
VL - 104
SP - 919
EP - 923
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 5
ER -