The Role of Mitochondrial Metabolism, AMPK-SIRT Mediated Pathway, LncRNA and MicroRNA in Osteoarthritis

Hao Yu Liu, Chi Fen Chang, Cheng Chang Lu, Shun Cheng Wu, Bin Huang, Tsung Lin Cheng, Sung Yen Lin, Cheng Jung Ho, Mon Juan Lee, Chung Da Yang, Ying Chun Wang, Jhong You Li, Ping Cheng Liu, Chun Wang Wei, Lin Kang, Chung Hwan Chen

Research output: Contribution to journalReview articlepeer-review

Abstract

Osteoarthritis (OA) is the most common joint disease characterized by degeneration of articular cartilage and causes severe joint pain, physical disability, and impaired quality of life. Recently, it was found that mitochondria not only act as a powerhouse of cells that provide energy for cellular metabolism, but are also involved in crucial pathways responsible for maintaining chondrocyte physiology. Therefore, a growing amount of evidence emphasizes that impairment of mitochondrial function is associated with OA pathogenesis; however, the exact mechanism is not well known. Moreover, the AMP-activated protein kinase (AMPK)–Sirtuin (SIRT) signaling pathway, long non-coding RNA (lncRNA), and microRNA (miRNA) are important for regulating the physiological and pathological processes of chondrocytes, indicating that these may be targets for OA treatment. In this review, we first focus on the importance of mitochondria metabolic dysregulation related to OA. Then, we show recent evidence on the AMPK-SIRT mediated pathway associated with OA pathogenesis and potential treatment options. Finally, we discuss current research into the effects of lncRNA and miRNA on OA progression or inhibition.

Original languageEnglish
Article number1477
JournalBiomedicines
Volume10
Issue number7
DOIs
Publication statusPublished - 2022 Jul

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)

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