The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats

Hua Chang Fang, Chien Liang Chen, Po Tsang Lee, Chih Yang Hsu, Ching Jiunn Tseng, Pei-Jung Lu, Shung Lon Lai, Hsiao Min Chung, Kang Ju Chou

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11 Citations (Scopus)

Abstract

To investigate the role of oxalate in star fruit neurotoxicity, rats were given star fruit or oxalate after a sham operation or modified five-sixths nephrectomy; namely, star fruit (SC) or oxalate (OxC) for sham-operated rats and star fruit (SNx), calcium gluconate treated star fruit juice (SCaNx), or oxalate (OxNx) for nephrectomized rats. After feedings, none of the rats in SC, OxC, and SCaNx groups developed movement disorders or died, while all rats in SNx group and OxNx group presented movement disorders and two rats in SNx group and four rats in OxNx group died within minute to hour after development of myoclonic jerk and/or tonic-clonic convulsion. The plasma oxalate levels rose significantly only in the SNx group and OxNx group that also presented clusters of generalized spike-waves in the electroencephalographic recordings. In conclusion, oxalate may play a key role in star fruit neurotoxicity in nephrectomized rats and probably in uremic patients.

Original languageEnglish
Pages (from-to)1764-1769
Number of pages6
JournalFood and Chemical Toxicology
Volume45
Issue number9
DOIs
Publication statusPublished - 2007 Sep 1

Fingerprint

Averrhoa carambola
neurotoxicity
Oxalates
oxalates
Fruits
Stars
Rats
Fruit
rats
movement disorders
Movement Disorders
Fruit juices
Tonic-Clonic Epilepsy
Calcium Gluconate
Myoclonus
fruit juices
seizures
Nephrectomy
Rosa
Plasmas

All Science Journal Classification (ASJC) codes

  • Food Science
  • Toxicology

Cite this

Fang, H. C., Chen, C. L., Lee, P. T., Hsu, C. Y., Tseng, C. J., Lu, P-J., ... Chou, K. J. (2007). The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats. Food and Chemical Toxicology, 45(9), 1764-1769. https://doi.org/10.1016/j.fct.2007.03.011
Fang, Hua Chang ; Chen, Chien Liang ; Lee, Po Tsang ; Hsu, Chih Yang ; Tseng, Ching Jiunn ; Lu, Pei-Jung ; Lai, Shung Lon ; Chung, Hsiao Min ; Chou, Kang Ju. / The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats. In: Food and Chemical Toxicology. 2007 ; Vol. 45, No. 9. pp. 1764-1769.
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Fang, HC, Chen, CL, Lee, PT, Hsu, CY, Tseng, CJ, Lu, P-J, Lai, SL, Chung, HM & Chou, KJ 2007, 'The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats', Food and Chemical Toxicology, vol. 45, no. 9, pp. 1764-1769. https://doi.org/10.1016/j.fct.2007.03.011

The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats. / Fang, Hua Chang; Chen, Chien Liang; Lee, Po Tsang; Hsu, Chih Yang; Tseng, Ching Jiunn; Lu, Pei-Jung; Lai, Shung Lon; Chung, Hsiao Min; Chou, Kang Ju.

In: Food and Chemical Toxicology, Vol. 45, No. 9, 01.09.2007, p. 1764-1769.

Research output: Contribution to journalArticle

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AU - Chen, Chien Liang

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AU - Lu, Pei-Jung

AU - Lai, Shung Lon

AU - Chung, Hsiao Min

AU - Chou, Kang Ju

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N2 - To investigate the role of oxalate in star fruit neurotoxicity, rats were given star fruit or oxalate after a sham operation or modified five-sixths nephrectomy; namely, star fruit (SC) or oxalate (OxC) for sham-operated rats and star fruit (SNx), calcium gluconate treated star fruit juice (SCaNx), or oxalate (OxNx) for nephrectomized rats. After feedings, none of the rats in SC, OxC, and SCaNx groups developed movement disorders or died, while all rats in SNx group and OxNx group presented movement disorders and two rats in SNx group and four rats in OxNx group died within minute to hour after development of myoclonic jerk and/or tonic-clonic convulsion. The plasma oxalate levels rose significantly only in the SNx group and OxNx group that also presented clusters of generalized spike-waves in the electroencephalographic recordings. In conclusion, oxalate may play a key role in star fruit neurotoxicity in nephrectomized rats and probably in uremic patients.

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