Abstract
The amygdala has long been known to play a central role in the acquisition and expression of fear. More recently, convergent evidence has implicated the amygdala in the extinction of fear as well. In rodents, some of this evidence comes from the infusion of drugs directly into the amygdala and, in particular, into the basolateral complex of the amygdala, during or after extinction learning. In vivo electrophysiology has identified cellular correlates of extinction learning and memory in the lateral nucleus of that structure. Human imaging experiments also indicate that amygdaloid activity correlates with extinction training. In addition, some studies have directly identified changes in molecular constituents of the basolateral amygdala. Together these experiments strongly indicate that the basolateral amygdala plays a crucial role in extinction learning. Interpreted in the light of these findings, several recent in vitro electrophysiology studies in amygdala-containing brain slices are suggestive of potential synaptic and circuit bases of extinction learning.
| Original language | English |
|---|---|
| Pages (from-to) | 322-328 |
| Number of pages | 7 |
| Journal | Biological Psychiatry |
| Volume | 60 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2006 Aug 15 |
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All Science Journal Classification (ASJC) codes
- Biological Psychiatry
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The Role of the Amygdala in the Extinction of Conditioned Fear. / Barad, Mark; Gean, Po-Wu; Lutz, Beat.
In: Biological Psychiatry, Vol. 60, No. 4, 15.08.2006, p. 322-328.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The Role of the Amygdala in the Extinction of Conditioned Fear
AU - Barad, Mark
AU - Gean, Po-Wu
AU - Lutz, Beat
PY - 2006/8/15
Y1 - 2006/8/15
N2 - The amygdala has long been known to play a central role in the acquisition and expression of fear. More recently, convergent evidence has implicated the amygdala in the extinction of fear as well. In rodents, some of this evidence comes from the infusion of drugs directly into the amygdala and, in particular, into the basolateral complex of the amygdala, during or after extinction learning. In vivo electrophysiology has identified cellular correlates of extinction learning and memory in the lateral nucleus of that structure. Human imaging experiments also indicate that amygdaloid activity correlates with extinction training. In addition, some studies have directly identified changes in molecular constituents of the basolateral amygdala. Together these experiments strongly indicate that the basolateral amygdala plays a crucial role in extinction learning. Interpreted in the light of these findings, several recent in vitro electrophysiology studies in amygdala-containing brain slices are suggestive of potential synaptic and circuit bases of extinction learning.
AB - The amygdala has long been known to play a central role in the acquisition and expression of fear. More recently, convergent evidence has implicated the amygdala in the extinction of fear as well. In rodents, some of this evidence comes from the infusion of drugs directly into the amygdala and, in particular, into the basolateral complex of the amygdala, during or after extinction learning. In vivo electrophysiology has identified cellular correlates of extinction learning and memory in the lateral nucleus of that structure. Human imaging experiments also indicate that amygdaloid activity correlates with extinction training. In addition, some studies have directly identified changes in molecular constituents of the basolateral amygdala. Together these experiments strongly indicate that the basolateral amygdala plays a crucial role in extinction learning. Interpreted in the light of these findings, several recent in vitro electrophysiology studies in amygdala-containing brain slices are suggestive of potential synaptic and circuit bases of extinction learning.
UR - http://www.scopus.com/inward/record.url?scp=33747066840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33747066840&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2006.05.029
DO - 10.1016/j.biopsych.2006.05.029
M3 - Review article
C2 - 16919522
AN - SCOPUS:33747066840
VL - 60
SP - 322
EP - 328
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 4
ER -