The role of the VEGF-C/VEGFR-3 axis in cancer progression

J. L. Su; C. J. Yen; P. S. Chen; S. E. Chuang; C. C. Hong; I. H. Kuo; H. Y. Chen; M. C. Hung; M. L. Kuo

doi:10.1038/sj.bjc.6603487

The role of the VEGF-C/VEGFR-3 axis in cancer progression

J. L. Su, C. J. Yen, P. S. Chen, S. E. Chuang, C. C. Hong, I. H. Kuo, H. Y. Chen, M. C. Hung, M. L. Kuo

Research output: Contribution to journal › Short survey › peer-review

223 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.

Original language	English
Pages (from-to)	541-545
Number of pages	5
Journal	British Journal of Cancer
Volume	96
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6603487
Publication status	Published - 2007 Feb 26

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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10.1038/sj.bjc.6603487

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title = "The role of the VEGF-C/VEGFR-3 axis in cancer progression",

abstract = "Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.",

author = "Su, {J. L.} and Yen, {C. J.} and Chen, {P. S.} and Chuang, {S. E.} and Hong, {C. C.} and Kuo, {I. H.} and Chen, {H. Y.} and Hung, {M. C.} and Kuo, {M. L.}",

note = "Funding Information: This work was supported by National Science Council, Taiwan, Grants NSC93-2323-B-002-007, NSC93-2320-B-002-019, and NSC93-23230-B-002-047; Taiwan Merit Scholarships TMS-094-2-B-023; Ministry of Economic Affairs, Taipei, Taiwan, Grant 93-EC-17-A-19-S1-0016; National Taiwan University Hospital Grant NTUH-93A15-3. This work was supported in part by the Odyssey Program and The Cockrell Foundation Award for Scientific Achievement at The University of Texas MD Anderson Cancer Center. The authors have declared that no conflict of interest exists.",

year = "2007",

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doi = "10.1038/sj.bjc.6603487",

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T1 - The role of the VEGF-C/VEGFR-3 axis in cancer progression

AU - Su, J. L.

AU - Yen, C. J.

AU - Chen, P. S.

AU - Chuang, S. E.

AU - Hong, C. C.

AU - Kuo, I. H.

AU - Chen, H. Y.

AU - Hung, M. C.

AU - Kuo, M. L.

N1 - Funding Information: This work was supported by National Science Council, Taiwan, Grants NSC93-2323-B-002-007, NSC93-2320-B-002-019, and NSC93-23230-B-002-047; Taiwan Merit Scholarships TMS-094-2-B-023; Ministry of Economic Affairs, Taipei, Taiwan, Grant 93-EC-17-A-19-S1-0016; National Taiwan University Hospital Grant NTUH-93A15-3. This work was supported in part by the Odyssey Program and The Cockrell Foundation Award for Scientific Achievement at The University of Texas MD Anderson Cancer Center. The authors have declared that no conflict of interest exists.

PY - 2007/2/26

Y1 - 2007/2/26

N2 - Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.

AB - Vascular endothelial growth factor (VEGF) receptor 3 (VEGFR-3) (also called VEGFR-3) is activated by its specific ligand, VEGF-C, which promotes cancer progression. The VEGF-C/VEGFR-3 axis is expressed not only by lymphatic endothelial cells but also by a variety of human tumour cells. Activation of the VEGF-C/VEGFR-3 axis in lymphatic endothelial cells can facilitate metastasis by increasing the formation of lymphatic vessels (lymphangiogenesis) within and around tumours. The VEGF-C/VEGFR-3 axis plays a critical role in leukaemic cell proliferation, survival, and resistance to chemotherapy. Moreover, activation of the VEGF-C/VEGFR-3 axis in several types of solid tumours enhances cancer cell mobility and invasion capabilities, promoting cancer cell metastasis. In this review, we discuss the novel function and molecular mechanism of the VEGF-C/VEGFR-3 axis in cancer progression.

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The role of the VEGF-C/VEGFR-3 axis in cancer progression

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