The role of thrombomodulin lectin-like domain in inflammation

Research output: Contribution to journalReview article

58 Citations (Scopus)

Abstract

Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity. In addition to its anticoagulant activity, recent evidence has revealed that TM, especially its lectin-like domain, has potent anti-inflammatory function through a variety of molecular mechanisms. The lectin-like domain of TM plays an important role in suppressing inflammation independent of the TM anticoagulant activity. This article makes an extensive review of the role of TM in inflammation. The molecular targets of TM lectin-like domain have also been elucidated. Recombinant TM protein, especially the TM lectin-like domain may play a promising role in the management of sepsis, glomerulonephritis and arthritis. These data demonstrated the potential therapeutic role of TM in the treatment of inflammatory diseases.

Original languageEnglish
Article number34
JournalJournal of biomedical science
Volume19
Issue number1
DOIs
Publication statusPublished - 2012 Mar 28

Fingerprint

Thrombomodulin
Lectins
Inflammation
Thrombin
Anticoagulants
Recombinant proteins
Membrane Glycoproteins
Glomerulonephritis
Protein C
Recombinant Proteins
Arthritis
Sepsis
Carrier Proteins
Anti-Inflammatory Agents
Chemical activation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

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The role of thrombomodulin lectin-like domain in inflammation. / Li, Yi Heng; Kuo, Cheng Hsiang; Shi, Guey Yueh; Wu, Hua Lin.

In: Journal of biomedical science, Vol. 19, No. 1, 34, 28.03.2012.

Research output: Contribution to journalReview article

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