Abstract
Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity. In addition to its anticoagulant activity, recent evidence has revealed that TM, especially its lectin-like domain, has potent anti-inflammatory function through a variety of molecular mechanisms. The lectin-like domain of TM plays an important role in suppressing inflammation independent of the TM anticoagulant activity. This article makes an extensive review of the role of TM in inflammation. The molecular targets of TM lectin-like domain have also been elucidated. Recombinant TM protein, especially the TM lectin-like domain may play a promising role in the management of sepsis, glomerulonephritis and arthritis. These data demonstrated the potential therapeutic role of TM in the treatment of inflammatory diseases.
| Original language | English |
|---|---|
| Article number | 34 |
| Journal | Journal of biomedical science |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2012 Mar 28 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Clinical Biochemistry
- Cell Biology
- Biochemistry, medical
- Pharmacology (medical)
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The role of thrombomodulin lectin-like domain in inflammation. / Li, Yi Heng; Kuo, Cheng Hsiang; Shi, Guey Yueh; Wu, Hua Lin.
In: Journal of biomedical science, Vol. 19, No. 1, 34, 28.03.2012.Research output: Contribution to journal › Review article
TY - JOUR
T1 - The role of thrombomodulin lectin-like domain in inflammation
AU - Li, Yi Heng
AU - Kuo, Cheng Hsiang
AU - Shi, Guey Yueh
AU - Wu, Hua Lin
PY - 2012/3/28
Y1 - 2012/3/28
N2 - Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity. In addition to its anticoagulant activity, recent evidence has revealed that TM, especially its lectin-like domain, has potent anti-inflammatory function through a variety of molecular mechanisms. The lectin-like domain of TM plays an important role in suppressing inflammation independent of the TM anticoagulant activity. This article makes an extensive review of the role of TM in inflammation. The molecular targets of TM lectin-like domain have also been elucidated. Recombinant TM protein, especially the TM lectin-like domain may play a promising role in the management of sepsis, glomerulonephritis and arthritis. These data demonstrated the potential therapeutic role of TM in the treatment of inflammatory diseases.
AB - Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity. In addition to its anticoagulant activity, recent evidence has revealed that TM, especially its lectin-like domain, has potent anti-inflammatory function through a variety of molecular mechanisms. The lectin-like domain of TM plays an important role in suppressing inflammation independent of the TM anticoagulant activity. This article makes an extensive review of the role of TM in inflammation. The molecular targets of TM lectin-like domain have also been elucidated. Recombinant TM protein, especially the TM lectin-like domain may play a promising role in the management of sepsis, glomerulonephritis and arthritis. These data demonstrated the potential therapeutic role of TM in the treatment of inflammatory diseases.
UR - http://www.scopus.com/inward/record.url?scp=84862791853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862791853&partnerID=8YFLogxK
U2 - 10.1186/1423-0127-19-34
DO - 10.1186/1423-0127-19-34
M3 - Review article
C2 - 22449172
AN - SCOPUS:84862791853
VL - 19
JO - Journal of Biomedical Science
JF - Journal of Biomedical Science
SN - 1021-7770
IS - 1
M1 - 34
ER -