The role of transcatheter arterial embolization in patients with resectable hepatocellular carcinoma: A nation-wide, multicenter study

Yi Hsiang Huang, Chien Hung Chen, Ting-Tsung Chang, Shinn Cherng Chen, Shen Yung Wang, Pui Ching Lee, Hsuan Shu Lee, Pin Wen Lin, Guan Tarn Huang, Jin Chuan Sheu, Hong-Ming Tsai, Gar Yang Chau, Jen Huei Chiang, Wing Yiu Liu, Shou Dong Lee, Jaw Ching Wu

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Purpose: The role of transcatheter arterial embolization (TAE) for patients with resectable hepatocellular carcinoma (HCC) is controversial. Analyzing a cohort of nation-wide data can delineate the beneficial effect of TAE for those patients. Methods: From 1991 to 1995, 818 patients who had potentially resectable HCC from four medical centers in Taiwan were enrolled. Among them, 599 underwent curative resection, 157 received TAE and 62 received supportive treatment alone. The survivals among the three groups were compared. Results: The 5-year survival rates for patients who underwent surgery, TAE and supportive treatment were 43.6%, 25.6% and 3.7%, respectively. Surgery offered the best survival for those patients. TAE could also prolong survival as compared with supportive treatment (P = 0.0001). However, among patients who were in advanced tumor stage (Cancer and the Liver Italian Program (CLIP) score ≥ 2), no statistical difference in survival was noted between patients who underwent TAE or supportive treatment. In multivariate analysis, single tumor, serum albumin ≥ 3.5 g/dl, tumor size less than 5 cm, early-stage tumor (CLIP score = 0-1) and aggressive treatment including surgery and TAE were independent factors associated with a better survival. Conclusions: Surgery is superior to TAE for patients with resectable HCC. In patients who refuse surgery, TAE can be considered for selected patients whose tumors are in early stage.

Original languageEnglish
Pages (from-to)419-424
Number of pages6
JournalLiver International
Volume24
Issue number5
DOIs
Publication statusPublished - 2004 Oct 1

All Science Journal Classification (ASJC) codes

  • Hepatology

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