The severity of Streptococcus pyogenes infections in children is significantly associated with plasma levels of inflammatory cytokines

Shih Min Wang, Ih Hui Lu, Ya Lan Lin, Yee Shin Lin, Jiunn Jong Wu, Woei Jer Chuang, Ming T. Lin, Ching Chuan Liu

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Cytokines are intimately involved with the innate and adaptive immune response to bacterial infections. This study was designed to determine the expression of inflammatory cytokines in children by the severity of Streptococcus pyogenes (group A Streptococcus [GAS]) infections. The study population consisted of 16 invasive, 20 noninvasive, and 24 pharyngeal colonization, and 21 healthy controls. All children underwent the laboratory tests and cytokine measurement. GAS isolates were analyzed for emm gene typing. Patients with invasive GAS diseases had significantly higher interferon (IFN)-γ, interleukin (IL)-1β, IL-6, IL-8, IL-10, and IL-18 than those with noninvasive diseases, colonization, and healthy controls. There was no difference in tumor necrosis factor (TNF)-α, IL-12, and IL-2 levels among the groups. Elevated white blood cell counts and levels of C-reactive protein and C3 were detected only in patients with invasive diseases. emm1 and emm12 predominated in invasive disease and colonization. Children with invasive GAS infections exhibited significant up-regulation of plasma levels of IFN-γ, IL-1β, IL-6, IL-8, IL-10, and IL-18, and suppression of TNF-α and IL-12 during the acute phase of their illness. An exuberant cytokine response was associated with the severity of illness.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalDiagnostic Microbiology and Infectious Disease
Volume61
Issue number2
DOIs
Publication statusPublished - 2008 Jun 1

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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