The study of anticardiolipin antibodies and interleukin-6 in cerebrospinal fluid and blood of chinese patients with systemic lupus erythematosus and central nervous system involvement

Tsann Sheng Yeh, Chrong Reen Wang, Geng Wang Jeng, Gwon Loon Lee, Mao Yuan Chen, Gong Ren Wang, Kuei Tang Lin, Che Yen Chuang, Chen Yen Chen

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22 Citations (Scopus)

Abstract

Anticardiolipin (ACL) antibodies and interleukin-6 (IL-6) in cerebrospinal fluid (CSF) may be involved in the mechanism of lupus patients with central nervous system (CNS) involvement. ACL antibodies of 3 isotypes and IL-6 were measured in paired CSF and serum samples from 14 lupus patients with CNS involvement, 5 lupus patients without CNS involvement and 7 patients with non-inflammatory neurological diseases. ACL antibodies, IgG and IgM isotypes, and IL-6 were significantly increased in CSF from lupus patients with CNS involvement as compared with other 2 groups of patients. Both ACL antibodies and IL-6 decreased after neurological activity subsided. These results suggest increased ACL antibodies and IL-6 in CSF are involved in immune responses within CNS in lupus patients. Quantitation of CSF ACL antibodies may be helpful in evaluating neurological activity of lupus patients with CNS involvement.

Original languageEnglish
Pages (from-to)169-175
Number of pages7
JournalAutoimmunity
Volume18
Issue number3
DOIs
Publication statusPublished - 1994 Jan 1

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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