The study of circulating CDS positive B lymphocytes in chinese patients with rheumatoid arthritis

S. T. Liu, C. R. Wang, M. F. Liu, J. S. Li, H. Y. Lei, C. Y. Chuang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Circulating CD5+ B lymphocytes were studied in 39 Chinese patients with rheumatoid arthritis (RA). Blood cells were stained with anti-CD5 and anti-CD 19 monoclonal antibodies and were analyzed by flow cytometry. The results showed that there was no elevation of CD5 + B cells in RA patients when compared with 41 healthy control subjects. The circulating levels of CD5 + B cell correlated neither with serum titers of rheumatoid factor (RF) nor with disease activities in these patients. The CD5+ B cell levels remained relatively constant after a serial follow-up for 12 months. The similar pattern of epitope density of CD5 antigens also existed in the same patients. Although most studies in Caucasians revealed increased levels of CD5 + B cells in RA patients, measurements of this marker were not useful for the evaluation of disease activities in Chinese patients. Levels of CD5 + B cells may reflect more individual genetic background and may play a minor role in the flare-up of activities in Chinese patients with RA.

Original languageEnglish
Pages (from-to)250-253
Number of pages4
JournalClinical Rheumatology
Volume15
Issue number3
DOIs
Publication statusPublished - 1996 Jan 1

All Science Journal Classification (ASJC) codes

  • Rheumatology

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