The study on the in-vitro stability of Tc(V)-99m dimercaptosuccinic acid

B. F. Lee, K. L. Chung, S. B. Jong, C. C. Yang, C. L. Chen, Y. J. Chen, S. L. Chen, H. S. Yu, G. Ting, L. H. Shen

Research output: Contribution to journalArticlepeer-review

Abstract

Tc(V)-99m DMS, developed by Yokoyama et al. in 1981, has been recognized to be advantageous for the scintigraphic diagnosis of various malignant tumors and their metastases. The aim of this study is to assess the in-vitro stability of Tc(V)-99m DMS. Thin-layer chromatography, including paper chromatography and silica gel thin layer chromatography, is performed to determine the change of radiochemical species presented in the reconstituted solution of Tc(V)-99m DMS prepared from the DMS kit (Institute of Nuclear Energy Research, Atomic Energy Council R.O.C.) and the commercial DMSA kit (Nephroscint, IRE CELLTARG Radiopharmaceuticals Japan). The bioscan imaging scanner is used to measure the Rf value and labeling efficiency of radiochemical species on the chromatographic strip. The in-vitro stability of Tc(V)-99m DMS prepared from the DMS kit and the commercial DMSA kit is studied by examining various parameters which include temperature (°C) and time (hr) after reconstitution. The results show that the in-vitro stability of Tc(V)-99m DMS prepared from the DMS kit is actually better than that from the commercial DMS kit. The one-step labeling method of DMS kit is much simpler than the two-step labeling method of DMSA kit.

Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalKaohsiung Journal of Medical Sciences
Volume12
Issue number9
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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