The three-body problem of therapy with induced pluripotent stem cells

Jakub Tolar; John A. McGrath

doi:10.1186/s13073-015-0141-7

The three-body problem of therapy with induced pluripotent stem cells

Jakub Tolar, John A. McGrath

Department of Dermatology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Regenerative medicine has a three-body problem: alignment of the dynamics of the genome, stem cell and patient. Focusing on the rare inherited fragile skin disorder epidermolysis bullosa, three recent innovative studies have used induced pluripotent stem cells and gene correction, revertant mosaicism or genome editing to advance the prospects of better cell-based therapeutics to restore skin structure and function for epidermolysis bullosa and potentially other inherited diseases.

Original language	English
Article number	15
Journal	Genome Medicine
Volume	7
Issue number	1
DOIs	https://doi.org/10.1186/s13073-015-0141-7
Publication status	Published - 2015 Feb 20

All Science Journal Classification (ASJC) codes

Molecular Medicine
Molecular Biology
Genetics
Genetics(clinical)

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10.1186/s13073-015-0141-7

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The three-body problem of therapy with induced pluripotent stem cells

Abstract

All Science Journal Classification (ASJC) codes

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