The transcriptional terminator sequences downstream of the covR gene terminate covR/S operon transcription to generate covR monocistronic transcripts in Streptococcus pyogenes

Chuan Chiang-Ni, Chih Cheng Tsou, Yee Shin Lin, Woei Jer Chuang, Ming T. Lin, Ching Chuan Liu, Jiunn Jong Wu

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

CovR/S is an important two component regulatory system, which regulates about 15% of the gene expression in Streptococcus pyogenes. The covR/S locus was identified as an operon generating an RNA transcript around 2.5-kb in size. In this study, we found the covR/S operon produced three RNA transcripts (around 2.5-, 1.0-, and 0.8-kb in size). Using RNA transcriptional terminator sequence prediction and transcriptional terminator analysis, we identified two atypical rho-independent terminator sequences downstream of the covR gene and showed these terminator sequences terminate RNA transcription efficiently. These results indicate that covR/S operon generates covR/S transcript and monocistronic covR transcripts.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalGene
Volume427
Issue number1-2
DOIs
Publication statusPublished - 2008 Dec 31

All Science Journal Classification (ASJC) codes

  • Genetics

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