The triterpenoids of Ganoderma tsugae prevent stress-induced myocardial injury in mice

Qian Yu Kuok, Chen Yu Yeh, Bor Chyuan Su, Pei Ling Hsu, Hao Ni, Ming Yie Liu, Fan E. Mo

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Ganoderma mushrooms (Lingzhi in Chinese) have well-documented health benefits. Ganoderma tsugae (G. tsugae), one of the ganoderma species, has been commercially cultivated as a dietary supplement. Because G. tsugae has high antioxidant activity and because oxidative stress is often associated with cardiac injury, we hypothesized that G. tsugae protects against cardiac injury by alleviating oxidative stress. We tested the hypothesis using a work-overload-induced myocardial injury model created by challenging mice with isoproterenol (ISO). Remarkably, oral G. tsugae protected the mice from ISO-induced myocardial injury. Moreover, the triterpenoid fraction of G. tsugae, composed of a mixture of nine structurally related ganoderic acids (GAs), provided cardioprotection by inhibiting the ISO-induced expression of Fas/Fas ligand, oxidative stress, and apoptosis. The antioxidant activity of GAs was tested in cultured cardio-myoblast H9c2 cells against the insult of H2O2. GAs dissipated the cellular reactive oxygen species imposed by H2O2 and prevented cell death. Our findings uncovered the cardioprotective activity of G. tsugae and identified GAs as the bioactive components against cardiac insults.

Original languageEnglish
Pages (from-to)1892-1896
Number of pages5
JournalMolecular Nutrition and Food Research
Issue number10
Publication statusPublished - 2013 Oct

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science


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