The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions

I. Ching Chou, Fuu Jen Tsai, Chao-Ching Huang, Cheng Chieh Lin, Chang Hai Tsai

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Mutations in the voltage-gated potassium channel genes KCNQ2 and KCNQ3 have been found to cause benign familial neonatal convulsions. Recent studies provided evidence that KCNQ2 and KCNQ3 contribute to the M-current, which regulates the sub-threshold electrical excitability in the CNS. Febrile convulsions represent the majority of childhood seizures, and show a strong family history, suggesting a genetic predisposition. By performing an association study, we investigated whether KCNQ2 gene polymorphisms can be used as markers of susceptibility to febrile convulsions. These data suggest that the KCNQ2 gene might not be a useful marker for prediction of the susceptibility of febrile convulsions.

Original languageEnglish
Pages (from-to)1971-1973
Number of pages3
JournalNeuroReport
Volume13
Issue number15
DOIs
Publication statusPublished - 2002 Oct 28

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Voltage-Gated Potassium Channels
Febrile Seizures
Benign Neonatal Epilepsy
Genes
Genetic Predisposition to Disease
Seizures
Mutation

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Chou, I. Ching ; Tsai, Fuu Jen ; Huang, Chao-Ching ; Lin, Cheng Chieh ; Tsai, Chang Hai. / The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions. In: NeuroReport. 2002 ; Vol. 13, No. 15. pp. 1971-1973.
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The voltage-gated potassium channel KCNQ2 in Taiwanese children with febrile convulsions. / Chou, I. Ching; Tsai, Fuu Jen; Huang, Chao-Ching; Lin, Cheng Chieh; Tsai, Chang Hai.

In: NeuroReport, Vol. 13, No. 15, 28.10.2002, p. 1971-1973.

Research output: Contribution to journalArticle

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