Therapeutic polymeric nanoparticles and the methods of making and using thereof: A patent evaluation of WO2015036792

Sailu Sarvagalla, Hsing Pang Hsieh, Mohane Selvaraj Coumar

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Evaluation of the patent application WO2015036792 claiming therapeutic polymeric nanoparticles loaded with AZD1152-hqpa (aurora kinase inhibitor), and methods of making and using same for the treatment of cancer, is described. The claimed polymeric nano-formulations containing hydrophobic acid significantly improved the pharmacokinetic profiles (slow/sustained drug release profile) of the drug AZD1152-hqpa, as compared to the control agent (AZD1152). Drug efficacy and tolerability were also improved, and toxicity decreased in in vivo animal experiments, resulting in a better therapeutic index for the nano-formulation. Hence, the nano-formulated AZD1152-hqpa could be tested in the clinic at a dose level similar to, or higher than, that used for AZD1152, with lower incidence of toxicity.

Original languageEnglish
Pages (from-to)751-755
Number of pages5
JournalExpert Opinion on Therapeutic Patents
Volume26
Issue number7
DOIs
Publication statusPublished - 2016 Jul 2

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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