Therapeutic Sesamol Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Rats by Inhibiting Matrix Metalloproteinase-9

Srinivasan Periasamy, Dur Zong Hsu, Shin Yi Chen, Shan Shan Yang, Victor Raj Mohan Chandrasekaran, Ming-Yi Liu

Research output: Contribution to journalArticle

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Abstract

We investigated the therapeutic effect of sesamol against monocrotaline-induced sinusoidal obstruction syndrome (SOS) in rats. Male Sprague-Dawley rats were gavaged with a single dose of monocrotaline (90 mg/kg) to induce SOS. Sesamol (5, 10, 20, and 40 mg/kg) was subcutaneously injected 24 h after monocrotaline treatment. Control rats were given saline only. Aspartate transaminase, alanine transaminase, mast cells, CD 68 + Kupffer cells, neutrophils, myeloperoxidase, matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), laminin, and collagen were assessed 48 h after monocrotaline treatment. All tested parameters, except for TIMP-1, laminin, and collagen, were significantly higher in monocrotaline-treated rats than in control rats, and, except for TIMP-1, laminin, and collagen, significantly lower in sesamol-treated rats than in monocrotaline-treated rats. In addition, liver pathology revealed that sesamol offered significant protection against SOS. We conclude that a single dose of sesamol therapeutically attenuated SOS by decreasing the recruitment of inflammatory cells, downregulating MMP-9, and upregulating TIMP-1 expression.

Original languageEnglish
Pages (from-to)327-336
Number of pages10
JournalCell Biochemistry and Biophysics
Volume61
Issue number2
DOIs
Publication statusPublished - 2011 Nov 1

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Hepatic Veno-Occlusive Disease
Monocrotaline
Matrix Metalloproteinase 9
Rats
Matrix Metalloproteinase 1
Tissue Inhibitor of Metalloproteinase-1
Laminin
Rat control
Tissue
Collagen
Therapeutics
Kupffer Cells
Therapeutic Uses
Pathology
Aspartate Aminotransferases
Alanine Transaminase
Mast Cells
Liver
Peroxidase
Sprague Dawley Rats

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Cell Biology

Cite this

Periasamy, Srinivasan ; Hsu, Dur Zong ; Chen, Shin Yi ; Yang, Shan Shan ; Chandrasekaran, Victor Raj Mohan ; Liu, Ming-Yi. / Therapeutic Sesamol Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Rats by Inhibiting Matrix Metalloproteinase-9. In: Cell Biochemistry and Biophysics. 2011 ; Vol. 61, No. 2. pp. 327-336.
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Therapeutic Sesamol Attenuates Monocrotaline-Induced Sinusoidal Obstruction Syndrome in Rats by Inhibiting Matrix Metalloproteinase-9. / Periasamy, Srinivasan; Hsu, Dur Zong; Chen, Shin Yi; Yang, Shan Shan; Chandrasekaran, Victor Raj Mohan; Liu, Ming-Yi.

In: Cell Biochemistry and Biophysics, Vol. 61, No. 2, 01.11.2011, p. 327-336.

Research output: Contribution to journalArticle

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