Thermosensitive chitosan-based hydrogel as a topical ocular drug delivery system of latanoprost for glaucoma treatment

Yung Hsin Cheng, Tung Hu Tsai, Yong Yu Jhan, Allen Wen Hsiang Chiu, Kun Ling Tsai, Chian Shiu Chien, Shih Hwa Chiou, Catherine Jui Lin Liu

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

Ocular hypertension is a major risk factor for the development and progression of glaucoma. Frequent and long-term application of latanoprost often causes undesirable local side effects, which are a major cause of therapeutic failure due to loss of persistence in using this glaucoma medical therapy. In the present study, we developed a thermosensitive chitosan-based hydrogel as a topical eye drop formulation for the sustained release of latanoprost to control ocular hypertension. The developed formulation without preservatives may improve compliance and possibly even efficacy. The results of this study support its biocompatibility and sustained-release profile both in vitro and in vivo. After topical application of latanoprost-loaded hydrogel, triamcinolone acetonide-induced elevated intraocular pressure was significantly decreased within 7 days and remained at a normal level for the following 21 days in rabbit eyes. This newly developed chitosan-based hydrogel may provide a non-invasive alternative to traditional anti-glaucoma eye drops for glaucoma treatment.

Original languageEnglish
Pages (from-to)390-399
Number of pages10
JournalCarbohydrate Polymers
Volume144
DOIs
Publication statusPublished - 2016 Jun 25

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry

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