Thymic neuroendocrine carcinoma and thymoma are both associated with increased risk of extrathymic malignancy: A 20-year review of a single institution

Yi Ting Yen, Wu Wei Lai, Ming Ho Wu, Mu Yen Lin, Jia Ming Chang, I. Lin Hsu, Yau Lin Tseng

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Abstract

Background Thymoma has been reported to have increased risk of extrathymic malignancy; thymic carcinoma, however, has not been validated of this association. We retrospectively assessed the incidence of additional malignancy among patients with thymoma and thymic carcinoma, and compared it with that of other solid organ cancers. Methods We reviewed the medical records between the years of 1988 and 2008 of 213 patients, including 131 with thymoma and 82 with thymic carcinoma. The overall incidence of additional malignancy in patients with thymic epithelial tumors, lung cancer, hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer between 2003 and 2008 in our institution was also computed. Results The incidence of extrathymic malignancy in patients with thymic epithelial tumors was 12.2% (16 of 131) for thymoma and 12.2% (10 of 82) for thymic carcinoma. The overall incidence of additional malignancy between 2003 and 2008 was significantly higher among patients with thymoma than among patients with hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer (p = 0.017, 0.022, 0.009, and 0.018, respectively). In thymic carcinoma, the likelihood of developing extrathymic malignancy was significantly higher among patients with neuroendocrine carcinoma than among patients with other thymic carcinomas (p = 0.000). Extrathymic neoplasm did not pose a significant influence on the overall survival of patients with thymoma (p = 0.085) and thymic carcinoma (p = 0.814). Conclusions Our data demonstrated the increased risk of extrathymic malignancies among patient with thymoma. In thymic carcinoma, this association mainly occurred in patients with neuroendocrine carcinoma. Actions for early detection of extrathymic malignancy should be considered for patients with these thymic epithelial tumors.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalAnnals of Thoracic Surgery
Volume91
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

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Neuroendocrine Carcinoma
Thymoma
Neoplasms
Breast Neoplasms
Incidence
Uterine Cervical Neoplasms
Hepatocellular Carcinoma
Colorectal Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

@article{a3241582f139488899d9e3ccb232b43d,
title = "Thymic neuroendocrine carcinoma and thymoma are both associated with increased risk of extrathymic malignancy: A 20-year review of a single institution",
abstract = "Background Thymoma has been reported to have increased risk of extrathymic malignancy; thymic carcinoma, however, has not been validated of this association. We retrospectively assessed the incidence of additional malignancy among patients with thymoma and thymic carcinoma, and compared it with that of other solid organ cancers. Methods We reviewed the medical records between the years of 1988 and 2008 of 213 patients, including 131 with thymoma and 82 with thymic carcinoma. The overall incidence of additional malignancy in patients with thymic epithelial tumors, lung cancer, hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer between 2003 and 2008 in our institution was also computed. Results The incidence of extrathymic malignancy in patients with thymic epithelial tumors was 12.2{\%} (16 of 131) for thymoma and 12.2{\%} (10 of 82) for thymic carcinoma. The overall incidence of additional malignancy between 2003 and 2008 was significantly higher among patients with thymoma than among patients with hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer (p = 0.017, 0.022, 0.009, and 0.018, respectively). In thymic carcinoma, the likelihood of developing extrathymic malignancy was significantly higher among patients with neuroendocrine carcinoma than among patients with other thymic carcinomas (p = 0.000). Extrathymic neoplasm did not pose a significant influence on the overall survival of patients with thymoma (p = 0.085) and thymic carcinoma (p = 0.814). Conclusions Our data demonstrated the increased risk of extrathymic malignancies among patient with thymoma. In thymic carcinoma, this association mainly occurred in patients with neuroendocrine carcinoma. Actions for early detection of extrathymic malignancy should be considered for patients with these thymic epithelial tumors.",
author = "Yen, {Yi Ting} and Lai, {Wu Wei} and Wu, {Ming Ho} and Lin, {Mu Yen} and Chang, {Jia Ming} and Hsu, {I. Lin} and Tseng, {Yau Lin}",
year = "2011",
month = "1",
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doi = "10.1016/j.athoracsur.2010.09.025",
language = "English",
volume = "91",
pages = "219--225",
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TY - JOUR

T1 - Thymic neuroendocrine carcinoma and thymoma are both associated with increased risk of extrathymic malignancy

T2 - A 20-year review of a single institution

AU - Yen, Yi Ting

AU - Lai, Wu Wei

AU - Wu, Ming Ho

AU - Lin, Mu Yen

AU - Chang, Jia Ming

AU - Hsu, I. Lin

AU - Tseng, Yau Lin

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background Thymoma has been reported to have increased risk of extrathymic malignancy; thymic carcinoma, however, has not been validated of this association. We retrospectively assessed the incidence of additional malignancy among patients with thymoma and thymic carcinoma, and compared it with that of other solid organ cancers. Methods We reviewed the medical records between the years of 1988 and 2008 of 213 patients, including 131 with thymoma and 82 with thymic carcinoma. The overall incidence of additional malignancy in patients with thymic epithelial tumors, lung cancer, hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer between 2003 and 2008 in our institution was also computed. Results The incidence of extrathymic malignancy in patients with thymic epithelial tumors was 12.2% (16 of 131) for thymoma and 12.2% (10 of 82) for thymic carcinoma. The overall incidence of additional malignancy between 2003 and 2008 was significantly higher among patients with thymoma than among patients with hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer (p = 0.017, 0.022, 0.009, and 0.018, respectively). In thymic carcinoma, the likelihood of developing extrathymic malignancy was significantly higher among patients with neuroendocrine carcinoma than among patients with other thymic carcinomas (p = 0.000). Extrathymic neoplasm did not pose a significant influence on the overall survival of patients with thymoma (p = 0.085) and thymic carcinoma (p = 0.814). Conclusions Our data demonstrated the increased risk of extrathymic malignancies among patient with thymoma. In thymic carcinoma, this association mainly occurred in patients with neuroendocrine carcinoma. Actions for early detection of extrathymic malignancy should be considered for patients with these thymic epithelial tumors.

AB - Background Thymoma has been reported to have increased risk of extrathymic malignancy; thymic carcinoma, however, has not been validated of this association. We retrospectively assessed the incidence of additional malignancy among patients with thymoma and thymic carcinoma, and compared it with that of other solid organ cancers. Methods We reviewed the medical records between the years of 1988 and 2008 of 213 patients, including 131 with thymoma and 82 with thymic carcinoma. The overall incidence of additional malignancy in patients with thymic epithelial tumors, lung cancer, hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer between 2003 and 2008 in our institution was also computed. Results The incidence of extrathymic malignancy in patients with thymic epithelial tumors was 12.2% (16 of 131) for thymoma and 12.2% (10 of 82) for thymic carcinoma. The overall incidence of additional malignancy between 2003 and 2008 was significantly higher among patients with thymoma than among patients with hepatocellular carcinoma, colorectal cancer, breast cancer, and cervical cancer (p = 0.017, 0.022, 0.009, and 0.018, respectively). In thymic carcinoma, the likelihood of developing extrathymic malignancy was significantly higher among patients with neuroendocrine carcinoma than among patients with other thymic carcinomas (p = 0.000). Extrathymic neoplasm did not pose a significant influence on the overall survival of patients with thymoma (p = 0.085) and thymic carcinoma (p = 0.814). Conclusions Our data demonstrated the increased risk of extrathymic malignancies among patient with thymoma. In thymic carcinoma, this association mainly occurred in patients with neuroendocrine carcinoma. Actions for early detection of extrathymic malignancy should be considered for patients with these thymic epithelial tumors.

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VL - 91

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JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

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