TIAF1 participates in the transforming growth factor β1-mediated growth regulation

Smaira Khera; Nan Shan Chang

doi:10.1111/j.1749-6632.2003.tb03206.x

TIAF1 participates in the transforming growth factor β1-mediated growth regulation

Smaira Khera, Nan Shan Chang

Institute of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

TGF-β induces growth suppression and apoptosis of various types of cells, but supports fibroblast growth. We previously isolated TIAF1 (TGF-β1-induced antiapoptotic factor 1), which protects murine L929 fibroblasts from TNF cytotoxicity. Here, we show that TIAF1 induced growth inhibition and apoptosis of monocytic U937 and other types of cells. In contrast, like TGF-β1, TIAF1 supported transforming growth of L929 fibroblasts. TIAF1 increased the expression of p53, Cip1/p21, and Smad proteins; suppressed ERK phosphorylation; and altered TGF-β1-mediated Smad2/3 phosphorylation in U937 cells. Antisense TIAF1 mRNA significantly enhanced the proliferation of mink lung Mv1Lu epithelial cells. Together, these observations indicate that TIAF1 participates in the TGF-β-mediated growth regulation.

Original language	English
Pages (from-to)	11-21
Number of pages	11
Journal	Annals of the New York Academy of Sciences
Volume	995
DOIs	https://doi.org/10.1111/j.1749-6632.2003.tb03206.x
Publication status	Published - 2003 Jan 1

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

Access to Document

10.1111/j.1749-6632.2003.tb03206.x

Fingerprint Dive into the research topics of 'TIAF1 participates in the transforming growth factor β1-mediated growth regulation'. Together they form a unique fingerprint.

Cite this

@article{d7df40ee13cd44ee9ea20afaf5fc59ae,

title = "TIAF1 participates in the transforming growth factor β1-mediated growth regulation",

abstract = "TGF-β induces growth suppression and apoptosis of various types of cells, but supports fibroblast growth. We previously isolated TIAF1 (TGF-β1-induced antiapoptotic factor 1), which protects murine L929 fibroblasts from TNF cytotoxicity. Here, we show that TIAF1 induced growth inhibition and apoptosis of monocytic U937 and other types of cells. In contrast, like TGF-β1, TIAF1 supported transforming growth of L929 fibroblasts. TIAF1 increased the expression of p53, Cip1/p21, and Smad proteins; suppressed ERK phosphorylation; and altered TGF-β1-mediated Smad2/3 phosphorylation in U937 cells. Antisense TIAF1 mRNA significantly enhanced the proliferation of mink lung Mv1Lu epithelial cells. Together, these observations indicate that TIAF1 participates in the TGF-β-mediated growth regulation.",

author = "Smaira Khera and Chang, {Nan Shan}",

year = "2003",

month = jan,

day = "1",

doi = "10.1111/j.1749-6632.2003.tb03206.x",

language = "English",

volume = "995",

pages = "11--21",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - TIAF1 participates in the transforming growth factor β1-mediated growth regulation

AU - Khera, Smaira

AU - Chang, Nan Shan

PY - 2003/1/1

Y1 - 2003/1/1

N2 - TGF-β induces growth suppression and apoptosis of various types of cells, but supports fibroblast growth. We previously isolated TIAF1 (TGF-β1-induced antiapoptotic factor 1), which protects murine L929 fibroblasts from TNF cytotoxicity. Here, we show that TIAF1 induced growth inhibition and apoptosis of monocytic U937 and other types of cells. In contrast, like TGF-β1, TIAF1 supported transforming growth of L929 fibroblasts. TIAF1 increased the expression of p53, Cip1/p21, and Smad proteins; suppressed ERK phosphorylation; and altered TGF-β1-mediated Smad2/3 phosphorylation in U937 cells. Antisense TIAF1 mRNA significantly enhanced the proliferation of mink lung Mv1Lu epithelial cells. Together, these observations indicate that TIAF1 participates in the TGF-β-mediated growth regulation.

AB - TGF-β induces growth suppression and apoptosis of various types of cells, but supports fibroblast growth. We previously isolated TIAF1 (TGF-β1-induced antiapoptotic factor 1), which protects murine L929 fibroblasts from TNF cytotoxicity. Here, we show that TIAF1 induced growth inhibition and apoptosis of monocytic U937 and other types of cells. In contrast, like TGF-β1, TIAF1 supported transforming growth of L929 fibroblasts. TIAF1 increased the expression of p53, Cip1/p21, and Smad proteins; suppressed ERK phosphorylation; and altered TGF-β1-mediated Smad2/3 phosphorylation in U937 cells. Antisense TIAF1 mRNA significantly enhanced the proliferation of mink lung Mv1Lu epithelial cells. Together, these observations indicate that TIAF1 participates in the TGF-β-mediated growth regulation.

UR - http://www.scopus.com/inward/record.url?scp=0038170348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038170348&partnerID=8YFLogxK

U2 - 10.1111/j.1749-6632.2003.tb03206.x

DO - 10.1111/j.1749-6632.2003.tb03206.x

M3 - Article

C2 - 12814935

AN - SCOPUS:0038170348

VL - 995

SP - 11

EP - 21

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -