Tissue expression of gelsolin in oral carcinogenesis progression and its clinicopathological implications

Dar Bin Shieh, I. Wen Chen, Tsai Yin Wei, Chuin Yi Shao, Hsin Ju Chang, Ching Hung Chung, Tung Yiu Wong, Ying Tai Jin

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Abstract

Gelsolin has important cellular functions, including cell motility, proliferation and apoptosis. Altered gelsolin expression has been reported in several types of human malignancies, but has not been evaluated in oral carcinogenesis. In this study, all normal oral mucosa (n = 12) had high gelsolin expression, whereas only 7.7% of oral precancerous lesions (n = 26) had positive gelsolin expression. A significant increased positive staining was found in primary (n = 51; 37.3%) and metastatic (n = 26; 30.8%) oral squamous cell carcinoma lesions. Tumors with high gelsolin expression were associated with greater tumour size (P = 0.007), invasive growth (P = 0.02), and younger age (P = 0.006). High gelsolin expression conferred a poor clinical outcome in patients with metastatic disease (P = 0.005). In conclusion, a biphasic profile in gelsolin expression was observed during the progression of oral carcinogenesis. This may be due to a balance of its multiple cellular functions in tumour invasion and cell growth. The underlying mechanisms, however, remain to be elucidated.

Original languageEnglish
Pages (from-to)599-606
Number of pages8
JournalOral Oncology
Volume42
Issue number6
DOIs
Publication statusPublished - 2006 Jul 1

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All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Oncology
  • Cancer Research

Cite this

Shieh, D. B., Chen, I. W., Wei, T. Y., Shao, C. Y., Chang, H. J., Chung, C. H., Wong, T. Y., & Jin, Y. T. (2006). Tissue expression of gelsolin in oral carcinogenesis progression and its clinicopathological implications. Oral Oncology, 42(6), 599-606. https://doi.org/10.1016/j.oraloncology.2005.10.021