Tissue-specific immunoglobulin E in maxillary sinus mucosa of allergic fungal sinusitis

Yu Tuan Chang, Sheen-Yie Fang

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Objective: The objectives of this prospective study were to analyze the specific immunoglobulin E (sIgE) in maxillary sinus mucosa and to determine the importance of local tissue AgE in the patients with allergic fungal sinusitis (AFS). Methods: We investigated tissue-specific IgE in the maxillary sinus mucosa. Thirty-four patients with rhinosinusitis and nasal polyposis were included in the study. The patients were divided into three groups - AFS, fungal sinusitis and chronic rhinosinusitis(CRS). The sIgE profile of the maxillary sinus mucosa was studied by the CAP method. Other parameters, such as allergic symptoms, presence of fungi hyphae and eosinophilic mucin in the sinus cavities as well as computed tomography (CT) scanning findings were also evaluated in all groups. Results: All patients in the AFS group had allergic symptoms, and the serum IgE test was positive to mites or house dust, but none had a positive serum IgE response to Aspergillus. However, 85.7% of this group had tissue sIgE to Aspergillus. Conclusions: The local tissue sIgE profile is more specific than the systemic AgE profile in determining the allergic status of ATS patients. Tissue sIgE for fungi may be considered as a part of AFS diagnostic criteria.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalRhinology
Volume46
Issue number3
Publication statusPublished - 2008 Sep 1

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Tissue-specific immunoglobulin E in maxillary sinus mucosa of allergic fungal sinusitis'. Together they form a unique fingerprint.

Cite this