Topical Tretinoin and Epithelial Wound Healing

Vincent C. Hung, Yu-Yun Lee, John A. Zitelli, Patricia A. Hebda

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The effects of topical tretinoin on epithelial wound healing were studied using a porcine model. Eight animals were treated with 0.05% tretinoin cream daily for ten days prior to partial-thickness skin wounding. Daily tretinoin treatment was continued after wounding on two of eight animals. Treatment with topical tretinoin before wounding accelerated epithelial wound healing in partial-thickness wounds. Continued tretinoin treatment on the wounds themselves retarded reepithelialization. Biopsy specimens of wounds with continued tretinoin treatment revealed persistent inflammation and fibroplasia in the dermis. The healing epithelium itself displayed areas of spongiosis and intracytoplasmic pale eosinophilic periodic acid-Schiff-positive, diastase-resistant globules. These globules did not stain with alcian blue. These epidermal alterations may be a direct effect of tretinoin or may be secondary to the underlying inflammation. While the dermal inflammation associated with continued tretinoin treatment appears to retard reepithelialization, epithelial cell alterations may also play a role.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalArchives of Dermatology
Volume125
Issue number1
DOIs
Publication statusPublished - 1989 Jan 1

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Tretinoin
Wound Healing
Inflammation
Wounds and Injuries
Alcian Blue
Skin
Periodic Acid
Amylases
Dermis
Coloring Agents
Swine
Epithelium
Epithelial Cells
Biopsy

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Dermatology

Cite this

Hung, Vincent C. ; Lee, Yu-Yun ; Zitelli, John A. ; Hebda, Patricia A. / Topical Tretinoin and Epithelial Wound Healing. In: Archives of Dermatology. 1989 ; Vol. 125, No. 1. pp. 65-69.
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Topical Tretinoin and Epithelial Wound Healing. / Hung, Vincent C.; Lee, Yu-Yun; Zitelli, John A.; Hebda, Patricia A.

In: Archives of Dermatology, Vol. 125, No. 1, 01.01.1989, p. 65-69.

Research output: Contribution to journalArticle

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