TY - JOUR
T1 - Tough and antifouling polyampholyte hydrogels via photopolymerization of equivalent ionic monomers with poly(ethylene glycol) diacrylate
AU - Wang, Po Hsin
AU - Lin, Chen Hsueh
AU - Wen, Ten Chin
N1 - Funding Information:
Ministry of Science and Technology of Taiwan and Center of Applied Nanomedicine (CAN) of National Cheng Kung University are acknowledged for the financial supports. Authors greatly acknowledged financial support from the Ministry of Science and Technology in Taiwan (MOST 106-2221-E-390-025 and MOST 108-2221-E-006 -159 -MY3).
Funding Information:
Ministry of Science and Technology of Taiwan and Center of Applied Nanomedicine (CAN) of National Cheng Kung University are acknowledged for the financial supports. Authors greatly acknowledged financial support from the Ministry of Science and Technology in Taiwan (MOST 106-2221-E-390-025 and MOST 108-2221-E-006 -159 -MY3 ).
Publisher Copyright:
© 2020 Taiwan Institute of Chemical Engineers
PY - 2020/8
Y1 - 2020/8
N2 - Tough and antifouling polyampholyte hydrogels can be prepared through the photopolymerization of the equivalent [2-(acryloyloxy)ethyl]trimethylammonium chloride([TMA][Cl]) and 2-acrylamido-2-methyl-1-propanesulfonic acid sodium([Na][AMPS]) with poly(ethylene glycol) diacrylate (PEGDA). Fourier-transform infrared spectra evidenced the linkage between PEGDA and TMA/AMPS. With the different ratios of TMA to AMPS, the copolymers presented the different morphological surfaces and also exhibited different swelling ratios. Among all copolymers, the equivalent ionic hydrogel A50S50 ([TMA] = [AMPS]) demonstrated the highest mechanical properties with toughness of 230.98 kJm-1 and compressive strain of 100%. Hydrogel A50S50 also presented the optimal protein fouling ability for both Bovine-serum-albumin (BSA, anionic protein) and Lysozyme (LYZ, cationic protein). On the other hand, A50S50 also showed the biocompatibility (low cytotoxicity and hemolytic ratio), being certified by MTT assay and hemolysis test. A polyampholyte A50S50 with equivalent ionic monomers possessed both tough and antifouling properties, being highly promising for load-bearing and antifouling biomedical applications.
AB - Tough and antifouling polyampholyte hydrogels can be prepared through the photopolymerization of the equivalent [2-(acryloyloxy)ethyl]trimethylammonium chloride([TMA][Cl]) and 2-acrylamido-2-methyl-1-propanesulfonic acid sodium([Na][AMPS]) with poly(ethylene glycol) diacrylate (PEGDA). Fourier-transform infrared spectra evidenced the linkage between PEGDA and TMA/AMPS. With the different ratios of TMA to AMPS, the copolymers presented the different morphological surfaces and also exhibited different swelling ratios. Among all copolymers, the equivalent ionic hydrogel A50S50 ([TMA] = [AMPS]) demonstrated the highest mechanical properties with toughness of 230.98 kJm-1 and compressive strain of 100%. Hydrogel A50S50 also presented the optimal protein fouling ability for both Bovine-serum-albumin (BSA, anionic protein) and Lysozyme (LYZ, cationic protein). On the other hand, A50S50 also showed the biocompatibility (low cytotoxicity and hemolytic ratio), being certified by MTT assay and hemolysis test. A polyampholyte A50S50 with equivalent ionic monomers possessed both tough and antifouling properties, being highly promising for load-bearing and antifouling biomedical applications.
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U2 - 10.1016/j.jtice.2020.08.027
DO - 10.1016/j.jtice.2020.08.027
M3 - Article
AN - SCOPUS:85091517780
VL - 113
SP - 101
EP - 106
JO - Journal of the Taiwan Institute of Chemical Engineers
JF - Journal of the Taiwan Institute of Chemical Engineers
SN - 1876-1070
ER -