TPH1 and 5-HTTLPR genes specifically interact in opiate dependence but not in alcohol dependence

Tzu Yun Wang, Sheng Yu Lee, Yi Lun Chung, Shiou Lan Chen, Chia Ling Li, Yun Hsuan Chang, Liang Jen Wang, Po See Chen, Shih Heng Chen, Chun Hsien Chu, San Yuan Huang, Nian Sheng Tzeng, Tsai Hsin Hsieh, I. Hui Lee, Kao Chin Chen, Yen Kuang Yang, Jau Shyong Hong, Ru Band Lu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. Methods: Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism. Results: The genotype frequencies of the TPH1 A218C polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 5-HTTLPR S+ (S/S, S/LG, LG/LG) polymorphisms were significantly higher in opiate-dependent patients (χ2 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients. Conclusions: Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed.

Original languageEnglish
Pages (from-to)201-209
Number of pages9
JournalEuropean Addiction Research
Issue number4
Publication statusPublished - 2016 Jun 1

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health(social science)
  • Psychiatry and Mental health


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