TPH1 and 5-HTTLPR genes specifically interact in opiate dependence but not in alcohol dependence

Tzu-Yun Wang, Sheng Yu Lee, Yi Lun Chung, Shiou Lan Chen, Chia Ling Li, Yun Hsuan Chang, Liang Jen Wang, Po-See Chen, Shih Heng Chen, Chun-Hsien Chu, San Yuan Huang, Nian Sheng Tzeng, Tsai Hsin Hsieh, I-Hui Lee, Kao-Ching Chen, Yen-Kuang Yang, Jau Shyong Hong, Ru-Band Lu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Background: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. Methods: Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism. Results: The genotype frequencies of the TPH1 A218C polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 5-HTTLPR S+ (S/S, S/LG, LG/LG) polymorphisms were significantly higher in opiate-dependent patients (χ2 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients. Conclusions: Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed.

Original languageEnglish
Pages (from-to)201-209
Number of pages9
JournalEuropean Addiction Research
Issue number4
Publication statusPublished - 2016 Jun 1

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health(social science)
  • Psychiatry and Mental health

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