TPMD

A database and resources of microsatellite marker genotyped in Taiwanese populations

Ya Hui Chang, Wen Hui Su, Tso Ching Lee, Hsiao-Fang Sun, Chia Hsiang Chen, Wen Harn Pan, Shih Feng Tsai, Yuh Shan Jou

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Taiwan Polymorphic Marker Database (TPMD) (http://tpmd.nhri.org.tw/) is a marker database designed to provide experimental details and useful marker information allelotyped in Taiwanese populations accompanied by resources and technical supports. The current version deposited more than 372 000 allelotyping data from 1425 frequently used and fluorescent-labeled microsatellite markers with variation types of dinucleotide, trinucleotide and tetranucleotide. TPMD contains text and map displays with searchable and retrievable options for marker names, chromosomal location in various human genome maps and marker heterozygosity in populations of Taiwanese, Japanese and Caucasian. The integration of marker information in map display is useful for the selection of high heterozygosity and commonly used microsatellite markers to refine mapping of diseases locus followed by identification of disease gene by positional candidate cloning. In addition, our results indicated that the number of markers with heterozygosity over 0.7 in Asian populations is lower than that in Caucasian. To increase accuracy and facilitate genetic studies using microsatellite markers, we also list markers with genotyping difficulty due to ambiguity of allele calling and recommend an optimal set of microsatellite markers for genotyping in Taiwanese, and possible extension of genotyping in other Mongoloid populations.

Original languageEnglish
JournalNucleic acids research
Volume33
Issue numberDATABASE ISS.
DOIs
Publication statusPublished - 2005 Jan 1

Fingerprint

Taiwan
Microsatellite Repeats
Databases
Population
Human Genome
Names
Organism Cloning
Alleles
Genes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Chang, Y. H., Su, W. H., Lee, T. C., Sun, H-F., Chen, C. H., Pan, W. H., ... Jou, Y. S. (2005). TPMD: A database and resources of microsatellite marker genotyped in Taiwanese populations. Nucleic acids research, 33(DATABASE ISS.). https://doi.org/10.1093/nar/gki102
Chang, Ya Hui ; Su, Wen Hui ; Lee, Tso Ching ; Sun, Hsiao-Fang ; Chen, Chia Hsiang ; Pan, Wen Harn ; Tsai, Shih Feng ; Jou, Yuh Shan. / TPMD : A database and resources of microsatellite marker genotyped in Taiwanese populations. In: Nucleic acids research. 2005 ; Vol. 33, No. DATABASE ISS.
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Chang, YH, Su, WH, Lee, TC, Sun, H-F, Chen, CH, Pan, WH, Tsai, SF & Jou, YS 2005, 'TPMD: A database and resources of microsatellite marker genotyped in Taiwanese populations', Nucleic acids research, vol. 33, no. DATABASE ISS.. https://doi.org/10.1093/nar/gki102

TPMD : A database and resources of microsatellite marker genotyped in Taiwanese populations. / Chang, Ya Hui; Su, Wen Hui; Lee, Tso Ching; Sun, Hsiao-Fang; Chen, Chia Hsiang; Pan, Wen Harn; Tsai, Shih Feng; Jou, Yuh Shan.

In: Nucleic acids research, Vol. 33, No. DATABASE ISS., 01.01.2005.

Research output: Contribution to journalArticle

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AU - Sun, Hsiao-Fang

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AU - Pan, Wen Harn

AU - Tsai, Shih Feng

AU - Jou, Yuh Shan

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