Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

Junxia Li, Fabo Shan, Gang Xiong, Ju Ming Wang, Wen Lin Wang, Xueqing Xu, Yun Bai

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume446
Issue number1
DOIs
Publication statusPublished - 2014 Mar 28

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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