Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

Junxia Li, Fabo Shan, Gang Xiong, Ju-Ming Wang, Wen Lin Wang, Xueqing Xu, Yun Bai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume446
Issue number1
DOIs
Publication statusPublished - 2014 Mar 28

Fingerprint

Esophageal Neoplasms
Up-Regulation
Cells
Cell proliferation
Transcription
Genetic Promoter Regions
Transcriptional Activation
Protein Isoforms
Genes
Chemical activation
Cell Proliferation
Apoptosis
Cell Line
Survival
Esophageal Squamous Cell Carcinoma
Epithelial Cells
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Li, Junxia ; Shan, Fabo ; Xiong, Gang ; Wang, Ju-Ming ; Wang, Wen Lin ; Xu, Xueqing ; Bai, Yun. / Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. In: Biochemical and Biophysical Research Communications. 2014 ; Vol. 446, No. 1. pp. 267-271.
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Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. / Li, Junxia; Shan, Fabo; Xiong, Gang; Wang, Ju-Ming; Wang, Wen Lin; Xu, Xueqing; Bai, Yun.

In: Biochemical and Biophysical Research Communications, Vol. 446, No. 1, 28.03.2014, p. 267-271.

Research output: Contribution to journalArticle

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