Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

Junxia Li; Fabo Shan; Gang Xiong; Ju Ming Wang; Wen Lin Wang; Xueqing Xu; Yun Bai

doi:10.1016/j.bbrc.2014.02.096

Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells

Junxia Li, Fabo Shan, Gang Xiong, Ju Ming Wang, Wen Lin Wang, Xueqing Xu, Yun Bai

Department of Biotechnology and Bioindustry Sciences

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.

Original language	English
Pages (from-to)	267-271
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	446
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2014.02.096
Publication status	Published - 2014 Mar 28

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Li, J., Shan, F., Xiong, G., Wang, J. M., Wang, W. L., Xu, X., & Bai, Y. (2014). Transcriptional regulation of miR-146b by C/EBPβ LAP2 in esophageal cancer cells. Biochemical and Biophysical Research Communications, 446(1), 267-271. https://doi.org/10.1016/j.bbrc.2014.02.096

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abstract = "Recent clinical study indicated that up-regulation of miR-146b was associated with poor overall survival of patients in esophageal squamous cell carcinoma. However, the underlying mechanism of miR-146b dysregulation remains to be explored. Here we report that miR-146b promotes cell proliferation and inhibits cell apoptosis in esophageal cancer cell lines. Mechanismly, two C/EBPβ binding motifs are located in the miR-146b promoter conserved region. Among the three isoforms of C/EBPβ, C/EBPβ LAP2 positively regulated miR-146b expression and increases miR-146b levels in a dose-dependent manner through transcription activation of miR-146b gene. Together, these results suggest a miR-146b regulatory mechanism involving C/EBPβ, which may contribute to the up-regulation of miR-146b in esophageal squamous cell carcinoma.",

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AU - Xu, Xueqing

AU - Bai, Yun

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