Transcriptome profiling reveals a novel role for trichostatin a in antagonizing histone chaperone Chz1 mediated telomere anti-silencing

Yakun Wan, Weiming Chen, Jie Xing, Jinyin Tan, Bing Li, Huiying Chen, Zhanxian Lin, Jung Hsien Chiang, Saleem Ramsey

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The histone chaperones play an important role in chromatin assembly and disassembly during replication and transcription. We have assessed the global roles of histone chaperones in Saccharomyces cerevisiae. Microarray transcriptional analyzes indicate that histone chaperones have their own specific target genes, and various histone chaperones have partially overlapping functions during transcriptional regulation. The histone deacetylase inhibitor TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel pathways to regulate transcription. Moreover, TSA can specifically antagonize histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates that a mutual cross-talk mechanism exists between histone chaperones and histone deacetylation in transcriptional regulation.

Original languageEnglish
Pages (from-to)2519-2525
Number of pages7
JournalFEBS Letters
Volume585
Issue number15
DOIs
Publication statusPublished - 2011 Aug 4

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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