Transformation kinetics and pathways of tetracycline antibiotics with manganese oxide

Wan Ru Chen, Ching Hua Huang

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Tetracycline antibiotics including tetracycline (TTC), oxytetracycline (OTC) and chlorotetracycline (CTC) undergo rapid transformation to yield various products in the presence of MnO2 at mild conditions (pH 4-9 and 22 °C). Reaction rates follow the trend of CTC > TTC > OTC, and are affected by pH and complexation of TCs with Mg2+ or Ca2+. Experimental results of TTC indicate that MnO2 promotes isomerization at the C ring to form iso-TTC and oxidizes the phenolic-diketone and tricarbonylamide groups, leading to insertion of up to 2 O most likely at the C9 and C2 positions. In contrast, reactions of OTC with MnO2 generate little iso-OTC, but occur mainly at the A ring's dimethylamine group to yield N-demethylated products. CTC yields the most complicated products upon reactions with MnO2, encompassing transformation patterns observed with both TTC and OTC. The identified product structures suggest lower antibacterial activity than that of the parent tetracyclines.

Original languageEnglish
Pages (from-to)1092-1100
Number of pages9
JournalEnvironmental Pollution
Volume159
Issue number5
DOIs
Publication statusPublished - 2011 May 1

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Manganese oxide
Antibiotics
Oxytetracycline
Isomerization
Tetracycline
Complexation
Reaction products
Reaction rates
Anti-Bacterial Agents
Chlortetracycline
Kinetics
Tetracyclines
manganese oxide

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

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abstract = "Tetracycline antibiotics including tetracycline (TTC), oxytetracycline (OTC) and chlorotetracycline (CTC) undergo rapid transformation to yield various products in the presence of MnO2 at mild conditions (pH 4-9 and 22 °C). Reaction rates follow the trend of CTC > TTC > OTC, and are affected by pH and complexation of TCs with Mg2+ or Ca2+. Experimental results of TTC indicate that MnO2 promotes isomerization at the C ring to form iso-TTC and oxidizes the phenolic-diketone and tricarbonylamide groups, leading to insertion of up to 2 O most likely at the C9 and C2 positions. In contrast, reactions of OTC with MnO2 generate little iso-OTC, but occur mainly at the A ring's dimethylamine group to yield N-demethylated products. CTC yields the most complicated products upon reactions with MnO2, encompassing transformation patterns observed with both TTC and OTC. The identified product structures suggest lower antibacterial activity than that of the parent tetracyclines.",
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Transformation kinetics and pathways of tetracycline antibiotics with manganese oxide. / Chen, Wan Ru; Huang, Ching Hua.

In: Environmental Pollution, Vol. 159, No. 5, 01.05.2011, p. 1092-1100.

Research output: Contribution to journalArticle

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AU - Huang, Ching Hua

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