TY - JOUR
T1 - Transforming growth factor-b (TGF-β) expression is increased in the subsynovial connective tissue in a rabbit model of carpal tunnel syndrome
AU - Chikenji, Takako
AU - Gingery, Anne
AU - Zhao, Chunfeng
AU - Vanhees, Matthias
AU - Moriya, Tamami
AU - Reisdorf, Ramona
AU - An, Kai Nan
AU - Amadio, Peter C.
N1 - Publisher Copyright:
© 2014 Chikenji et al.
PY - 2014/9/30
Y1 - 2014/9/30
N2 - Carpal tunnel syndrome (CTS) is an idiopathic disease that results from increased fibrosis of the subsynovial connective tissue (SSCT). A recent study found overexpression of both transforming growth factor-b (TGF-β) and connective tissue growth factor (CTGF) in the SSCT of CTS patients. This study investigated TGF-β and CTGF expression in a rabbit model of CTS, in which SSCT fibrosis is induced by a surgical injury. Levels of TGF-β1 and CTGF at 6, 12, 24 weeks after injury were determined by immunohistochemistry A significant increase in TGF-β1 and a concomitant significant increase in CTGF were found at 6 weeks, in addition to higher cell density compared to normal (all p<0.05), Interestingly, CTGF expression was reduced at 12 and 24 weeks, suggesting that an initial insult results in a time limited response. We conclude that this rabbit model mimics the fibrosis found in human CTS, and may be useful to study pathogenetic mechanisms of CTS in vivo.
AB - Carpal tunnel syndrome (CTS) is an idiopathic disease that results from increased fibrosis of the subsynovial connective tissue (SSCT). A recent study found overexpression of both transforming growth factor-b (TGF-β) and connective tissue growth factor (CTGF) in the SSCT of CTS patients. This study investigated TGF-β and CTGF expression in a rabbit model of CTS, in which SSCT fibrosis is induced by a surgical injury. Levels of TGF-β1 and CTGF at 6, 12, 24 weeks after injury were determined by immunohistochemistry A significant increase in TGF-β1 and a concomitant significant increase in CTGF were found at 6 weeks, in addition to higher cell density compared to normal (all p<0.05), Interestingly, CTGF expression was reduced at 12 and 24 weeks, suggesting that an initial insult results in a time limited response. We conclude that this rabbit model mimics the fibrosis found in human CTS, and may be useful to study pathogenetic mechanisms of CTS in vivo.
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U2 - 10.1371/journal.pone.0108312
DO - 10.1371/journal.pone.0108312
M3 - Article
C2 - 25269071
AN - SCOPUS:84907481629
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 9
M1 - e108312
ER -