Transient apoptosis elicited by insulin in serum-starved glioma cells involves Fas/Fas-L and Bcl-2

Bei Chang Yang, Yuh Sheng Wang, Cheng Hsin Wang, Hsi Hui Lin, Ming Jer Tang, Tsae Lian Yang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The expression of fas gene in glioma cells varies with growth stage. When insulin-elicited transient apoptosis of glioma cells was in progress, the expression of fas gene increased at both transcriptional and translational levels. In contrast, the expression of fas-L gene in glioma cells remained constant. Apoptosis occurred in the cells having high level of surface Fas protein. When the expression of Fas-L in U-373MG cells was suppressed by ribozyme, the insulin-elicited transient apoptosis vanished. Overexpression of Bcl-2 in U-373MG cells did not alter significantly the cell cycle progression and the expression of fas gene. However, these cells were resistant to insulin-trigged death. Therefore, insulin-elicited apoptosis involved Fas-related death signal, and which could be prevented by the protective effect of Bcl-2. (C) 1999 Academic Press.

Original languageEnglish
Pages (from-to)533-540
Number of pages8
JournalCell Biology International
Volume23
Issue number8
DOIs
Publication statusPublished - 1999 Aug

All Science Journal Classification (ASJC) codes

  • Cell Biology

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