Abstract
The expression of fas gene in glioma cells varies with growth stage. When insulin-elicited transient apoptosis of glioma cells was in progress, the expression of fas gene increased at both transcriptional and translational levels. In contrast, the expression of fas-L gene in glioma cells remained constant. Apoptosis occurred in the cells having high level of surface Fas protein. When the expression of Fas-L in U-373MG cells was suppressed by ribozyme, the insulin-elicited transient apoptosis vanished. Overexpression of Bcl-2 in U-373MG cells did not alter significantly the cell cycle progression and the expression of fas gene. However, these cells were resistant to insulin-trigged death. Therefore, insulin-elicited apoptosis involved Fas-related death signal, and which could be prevented by the protective effect of Bcl-2. (C) 1999 Academic Press.
Original language | English |
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Pages (from-to) | 533-540 |
Number of pages | 8 |
Journal | Cell Biology International |
Volume | 23 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1999 Aug |
All Science Journal Classification (ASJC) codes
- Cell Biology