Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection

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Abstract

The immune status after dengue virus infection was studied in dengue patients from an outbreak of serotype 3 dengue virus infection in the southern part of Taiwan during November and December 1998. Consecutive blood samples from 29 dengue patients, of whom 21 had dengue fever and 8 had dengue hemorrhagic fever/dengue shock syndrome, were collected, and the immunophenotypes of the peripheral blood mononuclear cells were determined by flow cytometry. The early activation marker CD69 appeared on lymphocytes and monocytes at day 4 after the onset of fever, and declined afterward. However, a transient reverse in the CD4/CD8 ratio occurred at days 6-10 after the onset of fever. The CD4/CD8 ratio inversion was manifested in 10 of 29 dengue patients and was encountered more frequently in dengue hemorrhagic fever/dengue shock syndrome than in dengue fever patients. Analysis of the clinical blood cell count of these 10 cases showed that increase of immature neutrophils developed at fever days 5-6, CD4dim or CD8dim monocytosis at days 6-7, and atypical lymphocytosis at days 8-10 after the onset of fever. Serum IL-6 was found at either day 7 or day 9-11. The PHA-stimulated T-cell response was depressed as well. These changes in immune parameters indicate aberrant immune activation during dengue virus infection and might be involved in the pathogenesis of dengue virus infection.

Original languageEnglish
Pages (from-to)241-252
Number of pages12
JournalJournal of Medical Virology
Volume68
Issue number2
DOIs
Publication statusPublished - 2002 Oct 1

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Severe Dengue
CD4-CD8 Ratio
Dengue Virus
Virus Diseases
Dengue
Fever
Lymphocytosis
Blood Cell Count
Taiwan
Disease Outbreaks
Monocytes
Interleukin-6
Blood Cells
Flow Cytometry
Neutrophils
Lymphocytes
T-Lymphocytes
Serum

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

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title = "Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection",
abstract = "The immune status after dengue virus infection was studied in dengue patients from an outbreak of serotype 3 dengue virus infection in the southern part of Taiwan during November and December 1998. Consecutive blood samples from 29 dengue patients, of whom 21 had dengue fever and 8 had dengue hemorrhagic fever/dengue shock syndrome, were collected, and the immunophenotypes of the peripheral blood mononuclear cells were determined by flow cytometry. The early activation marker CD69 appeared on lymphocytes and monocytes at day 4 after the onset of fever, and declined afterward. However, a transient reverse in the CD4/CD8 ratio occurred at days 6-10 after the onset of fever. The CD4/CD8 ratio inversion was manifested in 10 of 29 dengue patients and was encountered more frequently in dengue hemorrhagic fever/dengue shock syndrome than in dengue fever patients. Analysis of the clinical blood cell count of these 10 cases showed that increase of immature neutrophils developed at fever days 5-6, CD4dim or CD8dim monocytosis at days 6-7, and atypical lymphocytosis at days 8-10 after the onset of fever. Serum IL-6 was found at either day 7 or day 9-11. The PHA-stimulated T-cell response was depressed as well. These changes in immune parameters indicate aberrant immune activation during dengue virus infection and might be involved in the pathogenesis of dengue virus infection.",
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Transient CD4/CD8 ratio inversion and aberrant immune activation during dengue virus infection. / Liu, Ching-Chuan; Huang, Kao Jean; Lin, Yee-Shin; Yeh, Trai-Ming; Liu, Hsiao-Sheng; Lei, Huan Yao.

In: Journal of Medical Virology, Vol. 68, No. 2, 01.10.2002, p. 241-252.

Research output: Contribution to journalArticle

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