Transitional cell carcinoma in dialysis patients

Jiann Hui Ou, Cheng Chin Pan, Johnny Shinn Nan Lin, Tzong Shin Tzai, Wen Horng Yang, Chien Chen Chang, Hong Lin Cheng, Yung Ming Lin, Yat Ching Tong

Research output: Contribution to journalArticle

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Abstract

Objective: The aim of our study was to determine whether there is an increased incidence of urothelial cancer, especially transitional cell carcinoma (TCC), in uremic patients on dialysis. Methods: Retrospective chart analyses were completed for 1910 uremic patients undergoing maintenance dialysis between January 1987 and December 1997. The incidence of urinary tract cancer was assessed. Only the patients with cancers diagnosed after start of dialysis were enrolled in the study. Results. Of the 1910 patients, 70 had concomitant urinary tract cancers. Nineteen patients (0.99), including 17 patients with TCC and 2 patients with renal cell carcinoma, were diagnosed after the initiation of dialysis. The average duration from dialysis to TCC diagnosis was 38.3 (range 2-144) months. Painless gross hematuria was the cardinal symptom in 16 of the 17 patients with TCC. in the 17 patients with TCC, no distant metastases were found at the time of diagnosis. Fourteen patients (82.3) were stage O or A, and 1 patient was stage B1. Conclusions: The 0.89 incidence of TCC in our dialysis patients was high as compared with that of the general population. The risks of developing urinary TCC in dialysis patients were examined, and we suggest that immunosuppressive stage, dialysis procedure, and chronic bladder irritation (decreased urinary wash effect) may play a part in the development of urinary TCC in dialysis patients. Early detection of hematuria due to regular visits and decreased exposure of urinary tract epithelium to carcinogens from urine may explain why early-stage TCC was seen in most of our patients. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalEuropean Urology
Volume37
Issue number1
DOIs
Publication statusPublished - 2000 Jan 1

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Transitional Cell Carcinoma
Dialysis
Urologic Neoplasms
Hematuria
Incidence
Urothelium
Immunosuppressive Agents
Renal Cell Carcinoma
Carcinogens

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Ou, Jiann Hui ; Pan, Cheng Chin ; Lin, Johnny Shinn Nan ; Tzai, Tzong Shin ; Yang, Wen Horng ; Chang, Chien Chen ; Cheng, Hong Lin ; Lin, Yung Ming ; Tong, Yat Ching. / Transitional cell carcinoma in dialysis patients. In: European Urology. 2000 ; Vol. 37, No. 1. pp. 90-94.
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Transitional cell carcinoma in dialysis patients. / Ou, Jiann Hui; Pan, Cheng Chin; Lin, Johnny Shinn Nan; Tzai, Tzong Shin; Yang, Wen Horng; Chang, Chien Chen; Cheng, Hong Lin; Lin, Yung Ming; Tong, Yat Ching.

In: European Urology, Vol. 37, No. 1, 01.01.2000, p. 90-94.

Research output: Contribution to journalArticle

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AU - Ou, Jiann Hui

AU - Pan, Cheng Chin

AU - Lin, Johnny Shinn Nan

AU - Tzai, Tzong Shin

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AU - Cheng, Hong Lin

AU - Lin, Yung Ming

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