Traumatic brain injury increases β-amyloid peptide 1-42 in cerebrospinal fluid

Charlotte A. Raby, Maria C. Morganti-Kossmann, Thomas Kossmann, Philip F. Stahel, M. Desiree Watson, Lori M. Evans, Pankaj D. Mehta, Katharyn Spiegel, Yu Min Kuo, Alex E. Roher, Mark R. Emmerling

Research output: Contribution to journalArticlepeer-review

85 Citations (Scopus)

Abstract

The β-amyloid peptides, Aβ1-42 and Aβ1-40, were quantified in ventricular CSF taken daily for up to 3 weeks from six individuals with severe traumatic brain injury (-FBI). There was considerable interindividual variability in the levels of Aβ peptides, but in general Aβ1-42 levels equalled or exceeded those of Aβ1-40. Averaging the daily totals of our trauma cohort revealed that the levels of Aβ1-42 and Aβ1-40 rose after injury, peaking in the first week and then declining toward control levels over the next 2 weeks. Aβ1-42 levels were on average two to three times higher in the trauma cohort than in CSF from nontrauma samples. Compared with nontrauma samples, the Aβ1-40/Aβ1-42 ratio decreased about fivefold in the trauma patients, further indicative of increased Aβ1-42 levels. The ratio remained low at all time points studied. No change was measured in the levels of β-amyloid precursor protein during the same interval. These results suggest that Aβ1-42 becomes elevated in the CSF after severe brain trauma.

Original languageEnglish
Pages (from-to)2505-2509
Number of pages5
JournalJournal of Neurochemistry
Volume71
Issue number6
DOIs
Publication statusPublished - 1998 Dec

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

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