Treadmill exercise preconditioning attenuates lung damage caused by systemic endotoxemia in type 1 diabetic rats

Ching-Hsia Hung, Jann Inn Tzeng, Che Ning Chang, Yu Wen Chen, Chia Ying Cho, Jhi Joung Wang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Endotoxemia induces a series of inflammatory responses that may result in lung injury. However, heat shock protein72 (HSP72) has the potential to protect the lungs from damage. The objective of this study was to determine whether prior exercise conditioning could increase the expression of HSP72 in the lungs and attenuate lung damage in diabetic rats receiving lipopolysaccharide (LPS). Streptozotocin was used to induce diabetes in adult male Wistar rats. Rats were randomly assigned to sedentary or exercise groups. Rats in the exercise condition ran on a treadmill 5 days/week, 30-60 min/day, with an intensity of 1.0 mile/hour over a 3-week period. Rats received an intravenous infusion of LPS after 24 hrs from the last training session. Elevated lavage tumor necrosis factor-alpha (TNF-α) level in response to LPS was more marked in diabetic rats. HSP72 expression in lungs was significantly increased after exercise conditioning, but less pronounced in diabetic rats. After administration of LPS, exercised rats displayed higher survival rate as well as decreased lavage TNF-α level and lung edema in comparison to sedentary rats. Our findings suggest that exercise conditioning could attenuate the occurrence of inflammatory responses and lung damage, thereby reducing mortality rate in diabetic rats during endotoxemia.

Original languageEnglish
Article number527090
JournalJournal of Diabetes Research
Volume2013
DOIs
Publication statusPublished - 2013 Dec 1

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Endotoxemia
Lung
Lipopolysaccharides
Shock
Hot Temperature
Therapeutic Irrigation
Tumor Necrosis Factor-alpha
Lung Injury
Streptozocin
Intravenous Infusions
Wistar Rats
Edema
Survival Rate
Mortality

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Hung, Ching-Hsia ; Tzeng, Jann Inn ; Chang, Che Ning ; Chen, Yu Wen ; Cho, Chia Ying ; Wang, Jhi Joung. / Treadmill exercise preconditioning attenuates lung damage caused by systemic endotoxemia in type 1 diabetic rats. In: Journal of Diabetes Research. 2013 ; Vol. 2013.
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Treadmill exercise preconditioning attenuates lung damage caused by systemic endotoxemia in type 1 diabetic rats. / Hung, Ching-Hsia; Tzeng, Jann Inn; Chang, Che Ning; Chen, Yu Wen; Cho, Chia Ying; Wang, Jhi Joung.

In: Journal of Diabetes Research, Vol. 2013, 527090, 01.12.2013.

Research output: Contribution to journalArticle

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