Treadmill testing improves survival prediction models in pulmonary arterial hypertension

Chih Hsin Hsu; Cherylanne Glassner; Aimee J. Foreman; Richa Agarwal; Raymond J. Benza; Robert P. Frantz; Mardi Gomberg-Maitland

doi:10.1016/j.ahj.2011.09.015

Treadmill testing improves survival prediction models in pulmonary arterial hypertension

Chih Hsin Hsu, Cherylanne Glassner, Aimee J. Foreman, Richa Agarwal, Raymond J. Benza, Robert P. Frantz, Mardi Gomberg-Maitland

Department of Internal Medicine(NCKUH)

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: Six-minute walk distance (6MWD) is used in the REVEAL equation to predict 1-year survival for patients with pulmonary arterial hypertension. We sought to determine whether exercise treadmill testing (ETT) could be used in its place. Methods: This was a single-center study in which 449 patients were enrolled. The variables predictive of survival in the REVEAL equation were evaluated and compared with survival predicted by the REVEAL equation without an exercise measure and a revised equation using ETT. Results: The addition of ETT to the equation improved the predictive ability of the REVEAL equation in the high- and low-risk patient groups. Conclusion: The study findings suggest that the addition of ETT parameters to the REVEAL prognostic equation improves the predictive value of the equation when 6-minute walk distance is unavailable.

Original language	English
Pages (from-to)	1011-1017
Number of pages	7
Journal	American Heart Journal
Volume	162
Issue number	6
DOIs	https://doi.org/10.1016/j.ahj.2011.09.015
Publication status	Published - 2011 Dec

All Science Journal Classification (ASJC) codes

Cardiology and Cardiovascular Medicine

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10.1016/j.ahj.2011.09.015

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title = "Treadmill testing improves survival prediction models in pulmonary arterial hypertension",

abstract = "Background: Six-minute walk distance (6MWD) is used in the REVEAL equation to predict 1-year survival for patients with pulmonary arterial hypertension. We sought to determine whether exercise treadmill testing (ETT) could be used in its place. Methods: This was a single-center study in which 449 patients were enrolled. The variables predictive of survival in the REVEAL equation were evaluated and compared with survival predicted by the REVEAL equation without an exercise measure and a revised equation using ETT. Results: The addition of ETT to the equation improved the predictive ability of the REVEAL equation in the high- and low-risk patient groups. Conclusion: The study findings suggest that the addition of ETT parameters to the REVEAL prognostic equation improves the predictive value of the equation when 6-minute walk distance is unavailable.",

author = "Hsu, {Chih Hsin} and Cherylanne Glassner and Foreman, {Aimee J.} and Richa Agarwal and Benza, {Raymond J.} and Frantz, {Robert P.} and Mardi Gomberg-Maitland",

year = "2011",

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language = "English",

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journal = "American Heart Journal",

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T1 - Treadmill testing improves survival prediction models in pulmonary arterial hypertension

AU - Hsu, Chih Hsin

AU - Glassner, Cherylanne

AU - Foreman, Aimee J.

AU - Agarwal, Richa

AU - Benza, Raymond J.

AU - Frantz, Robert P.

AU - Gomberg-Maitland, Mardi

PY - 2011/12

Y1 - 2011/12

N2 - Background: Six-minute walk distance (6MWD) is used in the REVEAL equation to predict 1-year survival for patients with pulmonary arterial hypertension. We sought to determine whether exercise treadmill testing (ETT) could be used in its place. Methods: This was a single-center study in which 449 patients were enrolled. The variables predictive of survival in the REVEAL equation were evaluated and compared with survival predicted by the REVEAL equation without an exercise measure and a revised equation using ETT. Results: The addition of ETT to the equation improved the predictive ability of the REVEAL equation in the high- and low-risk patient groups. Conclusion: The study findings suggest that the addition of ETT parameters to the REVEAL prognostic equation improves the predictive value of the equation when 6-minute walk distance is unavailable.

AB - Background: Six-minute walk distance (6MWD) is used in the REVEAL equation to predict 1-year survival for patients with pulmonary arterial hypertension. We sought to determine whether exercise treadmill testing (ETT) could be used in its place. Methods: This was a single-center study in which 449 patients were enrolled. The variables predictive of survival in the REVEAL equation were evaluated and compared with survival predicted by the REVEAL equation without an exercise measure and a revised equation using ETT. Results: The addition of ETT to the equation improved the predictive ability of the REVEAL equation in the high- and low-risk patient groups. Conclusion: The study findings suggest that the addition of ETT parameters to the REVEAL prognostic equation improves the predictive value of the equation when 6-minute walk distance is unavailable.

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