Treatment effect of ‘ryu-wei-ti-huang-wan’ (a chinese herbal prescription) on the sexual performance of male rats with streptozotocin-lnduced diabetes

Yat-Ching Tong, Ying Cho Hung, Shinn Nan Lin, Juei Tang Cheng

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The treatment effect of ‘ryu-wei-ti-huang-wan’, a Chinese prescription composed of extracts from six plants, on diabetic impotence was evaluated in the present study. Adult male Wistar rats were divided into three groups: (1) rats rendered diabetic with a single intraperitoneal injection of streptozotocin (60 mg/kg body weight); (2) rats with streptozotocin-induced diabetes treated with a ryu-wei-ti-huang-wan powder preparation at a dose of 30 mg powder/kg body weight twice a day, and (3) control rats. A male rat was caged with an adult ovariectomized female rat during the dark cycle. Infra-red-light-illuminated video recording was utilized to evaluate the sexual performance. The diabetic rats exhibited depressed mounting activity and no intromission or ejaculation. After ryu-wei-ti-huang-wan treatment either for 1 day or 2 weeks, the diabetic rats showed significant improvement in mounting performance with preservation of intromission and ejaculation. No significant difference in the blood sugar level was noted between the treatment and non-treatment groups. In conclusion, the diabetic rats showed impairment in sexual arousal, erectile as well as ejaculatory functions. Ryu-wei-ti-huang-wan was effective in preserving these functions with a rapid onset. It is evident that the extracts exert the therapeutic effects not through a lowering of blood sugar. These substances are potentially useful in the clinical treatment of male diabetic impotence.

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalUrologia Internationalis
Volume57
Issue number4
DOIs
Publication statusPublished - 1996 Jan 1

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Experimental Diabetes Mellitus
Prescriptions
Ejaculation
Erectile Dysfunction
Therapeutics
Powders
Blood Glucose
Body Weight
Video Recording
Plant Extracts
Therapeutic Uses
Streptozocin
Arousal
Intraperitoneal Injections
Wistar Rats
Light

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

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abstract = "The treatment effect of ‘ryu-wei-ti-huang-wan’, a Chinese prescription composed of extracts from six plants, on diabetic impotence was evaluated in the present study. Adult male Wistar rats were divided into three groups: (1) rats rendered diabetic with a single intraperitoneal injection of streptozotocin (60 mg/kg body weight); (2) rats with streptozotocin-induced diabetes treated with a ryu-wei-ti-huang-wan powder preparation at a dose of 30 mg powder/kg body weight twice a day, and (3) control rats. A male rat was caged with an adult ovariectomized female rat during the dark cycle. Infra-red-light-illuminated video recording was utilized to evaluate the sexual performance. The diabetic rats exhibited depressed mounting activity and no intromission or ejaculation. After ryu-wei-ti-huang-wan treatment either for 1 day or 2 weeks, the diabetic rats showed significant improvement in mounting performance with preservation of intromission and ejaculation. No significant difference in the blood sugar level was noted between the treatment and non-treatment groups. In conclusion, the diabetic rats showed impairment in sexual arousal, erectile as well as ejaculatory functions. Ryu-wei-ti-huang-wan was effective in preserving these functions with a rapid onset. It is evident that the extracts exert the therapeutic effects not through a lowering of blood sugar. These substances are potentially useful in the clinical treatment of male diabetic impotence.",
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Treatment effect of ‘ryu-wei-ti-huang-wan’ (a chinese herbal prescription) on the sexual performance of male rats with streptozotocin-lnduced diabetes. / Tong, Yat-Ching; Hung, Ying Cho; Lin, Shinn Nan; Cheng, Juei Tang.

In: Urologia Internationalis, Vol. 57, No. 4, 01.01.1996, p. 230-234.

Research output: Contribution to journalArticle

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