Treatment of Langerhans-cell histiocytosis with multiple osseous lesions: Experience from A single case

Shan Wei Yang, Wen-Ying Chou, Chien Jen Hsu, Wei Ning Chang, Chi Hui Chen, Yi Jiun Chou, Chi Yin Wong

Research output: Contribution to journalArticle

Abstract

Langerhans-cell histiocytosis (LCH) is divided into Letterer-Siwe disease, Hand-Schuller-Christian disease, and Eosinophilic granuloma according to their presentations and severity. Eosinophilic granuloma is characterized by bony lesions and it affects older children or young adults. A 3-year-old boy presented with multiple osseous lesions of eosinophilic granuloma scattered over different bones. We treated the lesions of the left proximal femur and right distal femur with curettage and bone grafting. An intralesional injection of methyl-prednisolone was done for the lesions of the right distal humerus, left humeral shaft, right fibula and left glenoid fossa. Besides these, we observed lesions of the occipital skull, left pubic bone and right ilium. All of the lesions responded well to the above treatments without recurrence of previous lesions after four years of follow-up. A less invasive treatment should be suggested for osseous lesions of LCH, such as intralesional steroid injection or close observation. Curettage and bone grafting may be used for obtaining a tissue specimen for differential diagnosis. However, systemic chemotherapy or radiotherapy is not necessary for osseous lesions of LCH.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalFormosan Journal of Surgery
Volume35
Issue number3
Publication statusPublished - 2002 Jan 1

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Langerhans Cell Histiocytosis
Eosinophilic Granuloma
Intralesional Injections
Curettage
Bone Transplantation
Femur
Glenoid Cavity
Pubic Bone
Ilium
Therapeutics
Fibula
Humerus
Prednisolone
Skull
Young Adult
Differential Diagnosis
Radiotherapy
Steroids
Observation
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Yang, S. W., Chou, W-Y., Hsu, C. J., Chang, W. N., Chen, C. H., Chou, Y. J., & Wong, C. Y. (2002). Treatment of Langerhans-cell histiocytosis with multiple osseous lesions: Experience from A single case. Formosan Journal of Surgery, 35(3), 148-152.
Yang, Shan Wei ; Chou, Wen-Ying ; Hsu, Chien Jen ; Chang, Wei Ning ; Chen, Chi Hui ; Chou, Yi Jiun ; Wong, Chi Yin. / Treatment of Langerhans-cell histiocytosis with multiple osseous lesions : Experience from A single case. In: Formosan Journal of Surgery. 2002 ; Vol. 35, No. 3. pp. 148-152.
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abstract = "Langerhans-cell histiocytosis (LCH) is divided into Letterer-Siwe disease, Hand-Schuller-Christian disease, and Eosinophilic granuloma according to their presentations and severity. Eosinophilic granuloma is characterized by bony lesions and it affects older children or young adults. A 3-year-old boy presented with multiple osseous lesions of eosinophilic granuloma scattered over different bones. We treated the lesions of the left proximal femur and right distal femur with curettage and bone grafting. An intralesional injection of methyl-prednisolone was done for the lesions of the right distal humerus, left humeral shaft, right fibula and left glenoid fossa. Besides these, we observed lesions of the occipital skull, left pubic bone and right ilium. All of the lesions responded well to the above treatments without recurrence of previous lesions after four years of follow-up. A less invasive treatment should be suggested for osseous lesions of LCH, such as intralesional steroid injection or close observation. Curettage and bone grafting may be used for obtaining a tissue specimen for differential diagnosis. However, systemic chemotherapy or radiotherapy is not necessary for osseous lesions of LCH.",
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Yang, SW, Chou, W-Y, Hsu, CJ, Chang, WN, Chen, CH, Chou, YJ & Wong, CY 2002, 'Treatment of Langerhans-cell histiocytosis with multiple osseous lesions: Experience from A single case', Formosan Journal of Surgery, vol. 35, no. 3, pp. 148-152.

Treatment of Langerhans-cell histiocytosis with multiple osseous lesions : Experience from A single case. / Yang, Shan Wei; Chou, Wen-Ying; Hsu, Chien Jen; Chang, Wei Ning; Chen, Chi Hui; Chou, Yi Jiun; Wong, Chi Yin.

In: Formosan Journal of Surgery, Vol. 35, No. 3, 01.01.2002, p. 148-152.

Research output: Contribution to journalArticle

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