Treatment results and prognostic factors for locally advanced buccal cancer

Feng Chun Hsu, Tze-Ta Huang, Wen Yen Chiou, Ching Chih Lee, Moon Sing Lee, Shih Hsuan Hsiao, Hon Yi Lin, Yu Chieh Su, Shih Kai Hung

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Abstract

Objective: The aim of this study was to retrospectively analyze locally advanced buccal cancer in order to determine tumor characteristics and any other prognostic factors that may influence the survival of patients with the disease. Patients and Methods: The records of 54 patients with stage III to IV locally advanced buccal cancer (TNM system) who were seen from August 2000 to June 2008 at one institution were reviewed. The patients received radical surgery and then adjuvant treatment. The adjuvant treatment in cluded concurrent chemoradiotherapy or radiotherapy alone. The chemotherapy protocol consisted of two 4-weekly courses of concurrent cisplatin and 5-fluorouracil followed by another two 4-weekly courses after radiotherapy, with regimens of cisplatin (60-100 mg/m2/day) on day 1 and 5-fluorouracil (1000 mg/m2/day) on days 1-5. Results: The 3-year cumulative overall survival, disease-specific survival, disease-free survival, locoregional control, and distant metastasis-free survival rates were 66%, 69%, 58%, 65%, and 92%, respectively. Univariate analysis indicated that the pN classification, the surgical margin, and the presence of extracapsular spread were significantly associated with overall survival. On multivariate analysis, pN classification and surgical margin significantly affected disease-free survival. The pN classification (pN0 vs. pN1-3) and the surgical margin (< 1 vs.≥ 1 mm) were the two most significant factors affecting clinical outcome. Conclusion: The presence of lymph node involvement, the presence of extracapsular spread and a surgical margin < 1 mm were strong prognostic factors that were associated with tumor control. More aggressive postoperative therapy is suggested for patients with buccal mucosa carcinoma if these factors exist.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalTzu Chi Medical Journal
Volume22
Issue number2
DOIs
Publication statusPublished - 2010 Jun 1

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hsu, F. C., Huang, T-T., Chiou, W. Y., Lee, C. C., Lee, M. S., Hsiao, S. H., Lin, H. Y., Su, Y. C., & Hung, S. K. (2010). Treatment results and prognostic factors for locally advanced buccal cancer. Tzu Chi Medical Journal, 22(2), 96-102. https://doi.org/10.1016/S1016-3190(10)60048-1