Treatment results and prognostic factors for locally advanced buccal cancer

Feng Chun Hsu, Tze-Ta Huang, Wen Yen Chiou, Ching Chih Lee, Moon Sing Lee, Shih Hsuan Hsiao, Hon Yi Lin, Yu Chieh Su, Shih Kai Hung

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to retrospectively analyze locally advanced buccal cancer in order to determine tumor characteristics and any other prognostic factors that may influence the survival of patients with the disease. Patients and Methods: The records of 54 patients with stage III to IV locally advanced buccal cancer (TNM system) who were seen from August 2000 to June 2008 at one institution were reviewed. The patients received radical surgery and then adjuvant treatment. The adjuvant treatment in cluded concurrent chemoradiotherapy or radiotherapy alone. The chemotherapy protocol consisted of two 4-weekly courses of concurrent cisplatin and 5-fluorouracil followed by another two 4-weekly courses after radiotherapy, with regimens of cisplatin (60-100 mg/m2/day) on day 1 and 5-fluorouracil (1000 mg/m2/day) on days 1-5. Results: The 3-year cumulative overall survival, disease-specific survival, disease-free survival, locoregional control, and distant metastasis-free survival rates were 66%, 69%, 58%, 65%, and 92%, respectively. Univariate analysis indicated that the pN classification, the surgical margin, and the presence of extracapsular spread were significantly associated with overall survival. On multivariate analysis, pN classification and surgical margin significantly affected disease-free survival. The pN classification (pN0 vs. pN1-3) and the surgical margin (< 1 vs.≥ 1 mm) were the two most significant factors affecting clinical outcome. Conclusion: The presence of lymph node involvement, the presence of extracapsular spread and a surgical margin < 1 mm were strong prognostic factors that were associated with tumor control. More aggressive postoperative therapy is suggested for patients with buccal mucosa carcinoma if these factors exist.

Original languageEnglish
Pages (from-to)96-102
Number of pages7
JournalTzu Chi Medical Journal
Volume22
Issue number2
DOIs
Publication statusPublished - 2010 Jun 1

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Cheek
Survival
Neoplasms
Fluorouracil
Cisplatin
Disease-Free Survival
Radiotherapy
Therapeutics
Mouth Mucosa
Chemoradiotherapy
Multivariate Analysis
Survival Rate
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Drug Therapy
Margins of Excision

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Hsu, F. C., Huang, T-T., Chiou, W. Y., Lee, C. C., Lee, M. S., Hsiao, S. H., ... Hung, S. K. (2010). Treatment results and prognostic factors for locally advanced buccal cancer. Tzu Chi Medical Journal, 22(2), 96-102. https://doi.org/10.1016/S1016-3190(10)60048-1
Hsu, Feng Chun ; Huang, Tze-Ta ; Chiou, Wen Yen ; Lee, Ching Chih ; Lee, Moon Sing ; Hsiao, Shih Hsuan ; Lin, Hon Yi ; Su, Yu Chieh ; Hung, Shih Kai. / Treatment results and prognostic factors for locally advanced buccal cancer. In: Tzu Chi Medical Journal. 2010 ; Vol. 22, No. 2. pp. 96-102.
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Hsu, FC, Huang, T-T, Chiou, WY, Lee, CC, Lee, MS, Hsiao, SH, Lin, HY, Su, YC & Hung, SK 2010, 'Treatment results and prognostic factors for locally advanced buccal cancer', Tzu Chi Medical Journal, vol. 22, no. 2, pp. 96-102. https://doi.org/10.1016/S1016-3190(10)60048-1

Treatment results and prognostic factors for locally advanced buccal cancer. / Hsu, Feng Chun; Huang, Tze-Ta; Chiou, Wen Yen; Lee, Ching Chih; Lee, Moon Sing; Hsiao, Shih Hsuan; Lin, Hon Yi; Su, Yu Chieh; Hung, Shih Kai.

In: Tzu Chi Medical Journal, Vol. 22, No. 2, 01.06.2010, p. 96-102.

Research output: Contribution to journalArticle

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T1 - Treatment results and prognostic factors for locally advanced buccal cancer

AU - Hsu, Feng Chun

AU - Huang, Tze-Ta

AU - Chiou, Wen Yen

AU - Lee, Ching Chih

AU - Lee, Moon Sing

AU - Hsiao, Shih Hsuan

AU - Lin, Hon Yi

AU - Su, Yu Chieh

AU - Hung, Shih Kai

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N2 - Objective: The aim of this study was to retrospectively analyze locally advanced buccal cancer in order to determine tumor characteristics and any other prognostic factors that may influence the survival of patients with the disease. Patients and Methods: The records of 54 patients with stage III to IV locally advanced buccal cancer (TNM system) who were seen from August 2000 to June 2008 at one institution were reviewed. The patients received radical surgery and then adjuvant treatment. The adjuvant treatment in cluded concurrent chemoradiotherapy or radiotherapy alone. The chemotherapy protocol consisted of two 4-weekly courses of concurrent cisplatin and 5-fluorouracil followed by another two 4-weekly courses after radiotherapy, with regimens of cisplatin (60-100 mg/m2/day) on day 1 and 5-fluorouracil (1000 mg/m2/day) on days 1-5. Results: The 3-year cumulative overall survival, disease-specific survival, disease-free survival, locoregional control, and distant metastasis-free survival rates were 66%, 69%, 58%, 65%, and 92%, respectively. Univariate analysis indicated that the pN classification, the surgical margin, and the presence of extracapsular spread were significantly associated with overall survival. On multivariate analysis, pN classification and surgical margin significantly affected disease-free survival. The pN classification (pN0 vs. pN1-3) and the surgical margin (< 1 vs.≥ 1 mm) were the two most significant factors affecting clinical outcome. Conclusion: The presence of lymph node involvement, the presence of extracapsular spread and a surgical margin < 1 mm were strong prognostic factors that were associated with tumor control. More aggressive postoperative therapy is suggested for patients with buccal mucosa carcinoma if these factors exist.

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