Treatment with dextromethorphan improves endothelial function, inflammation and oxidative stress in male heavy smokers

P. Y. Liu, C. C. Lin, W. C. Tsai, Y. H. Li, L. J. Lin, G. Y. Shi, J. S. Hong, J. H. Chen, Hua Lin Wu

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12 Citations (Scopus)

Abstract

Background: Dextromethorphan (DM) is reported to reduce the inflammation-mediated degeneration of dopaminergic neurons. Objective: The goal of this study was to test if DM can improve the endothelial dysfunction and inflammatory markers in heavy smokers. Patients and methods: Forty habitual smoking healthy male volunteers (mean age, 31.5±1.4 years) were randomly given either DM (120 mg day-1) or a placebo for 6 months. We determined endothelial function using the brachial artery diameter changes in flow-mediated dilatation (FMD) and measured their inflammatory and oxidative markers. A sex-and-age matched non-smoking group (n = 20) was compared as normal parameters. Results: Habitual smokers showed impaired baseline endothelial function in FMD (smoking vs. non-smoking: 6.3±1.8 vs. 10.2±2.3% respectively, P < 0.01). Without change in smoking behavior, lipid and metabolic parameters, a significant increase in FMD was found in the DM-treated group (32%), accompanied by a decrease in high-sensitivity C-reactive protein (hs-CRP), phospholipase A2, matrix metalloproteinase-3, interleukin 6 (IL-6) and tumor necrosis factor-α receptor II (TNF-α RII) (all P < 0.05), but unchanged in von Willebrand factor (VWF)and plasminogen activator inhibitor-1 (PAI-1). An increase in plasma glutathione peroxidase and a decrease in spot urinary excretion of 8-epi-prostaglandin F2a were found in DM-treated smokers. Conclusions: Our study suggests that a 6-month treatment with DM can improve endothelial function and attenuate vascular oxidative stress and inflammation markers in habitual smokers.

Original languageEnglish
Pages (from-to)1685-1692
Number of pages8
JournalJournal of Thrombosis and Haemostasis
Volume6
Issue number10
DOIs
Publication statusPublished - 2008

All Science Journal Classification (ASJC) codes

  • Hematology

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